The Relationship between Bladder Cancer and Epigenetic Alterations
Journal Title: Üroonkoloji Bülteni - Year 2017, Vol 16, Issue 1
Abstract
Bladder cancer is one of the most common cancers of urinary system and approximately 70% of the cases are low grade and non-muscle invasive. Because of the histological indicator inadequacy of heterogeneous tumors like bladder cancer, researchers tend to look into genetic and molecular markers. Furthermore, role of epigenetic changes in cancer biology to be more distinctive than other cellular changes was shown. Epigenetic changes include 3 main titles; DNA methylation, micro RNA regulation and histone modification. In the literature, many epigenetic changes were found to be associated with early detection of the disease, progression, patient prognosis, tumor recurrence, early relapse, higher pathologic stage, disease-specific survival. With the understanding of epigenetic changes better patient outcomes will be achieved in the future.
Authors and Affiliations
Ata Özen, Ali Ülgen, Cavit Can
Keywords
Related Articles
- EP ID EP226741
- DOI 10.4274/uob.566
- Views 96
- Downloads 0
Significance of Pretreatment Testosterone Levels in Prostate Cancer Risk Groups
Objective: In this report, patients, who had testosterone (TE) level data before prostate needle biopsy and who later underwent radical prostatectomy (RP) due to prostate adenocarcinoma, were evaluated. The TE levels wer...
The Prostatic Urethral Lift Method: A New Minimally Invasive Modality as an Alternative in the Treatment of Benign Prostatic Hyperplasia
Improvements in the treatment of benign prostatic hyperplasia (BPH), which is the most common cause of lower urinary tract symptoms in aging males, are proceeding progressively. The prostatic urethral lift procedure offe...
A Rare Presentation of Germ Cell Neoplasia: Persistant Müllerian Duct Syndrome
Persistent Müllerian duct syndrome is a rare form of pseudohermaphroditism. This article is made of two case reports showing malignant transformation. The first case was a 36-year-old male who presented with infertility....
Positron Emission Tomography in Renal Cell Carcinoma
Renal cell carcinoma is the most common solid kidney tumor. Conventional methods such as computed tomography and magnetic resonance imaging are usually chosen for diagnosis, staging, and evaluating recurrence and treatme...
Risk Adaptive Neoadjuvant Chemotherapy in Muscle Invasive Bladder Cancer
Muscle invasive bladder cancer (MIBC) is an aggressive tumor with a high rate of early systemic dissemination. The main treatment for MIBC is still radical cystectomy and lymph node dissection. Survival rates for 5-year...