The Relationship between Bladder Cancer and Epigenetic Alterations
Journal Title: Üroonkoloji Bülteni - Year 2017, Vol 16, Issue 1
Abstract
Bladder cancer is one of the most common cancers of urinary system and approximately 70% of the cases are low grade and non-muscle invasive. Because of the histological indicator inadequacy of heterogeneous tumors like bladder cancer, researchers tend to look into genetic and molecular markers. Furthermore, role of epigenetic changes in cancer biology to be more distinctive than other cellular changes was shown. Epigenetic changes include 3 main titles; DNA methylation, micro RNA regulation and histone modification. In the literature, many epigenetic changes were found to be associated with early detection of the disease, progression, patient prognosis, tumor recurrence, early relapse, higher pathologic stage, disease-specific survival. With the understanding of epigenetic changes better patient outcomes will be achieved in the future.
Authors and Affiliations
Ata Özen, Ali Ülgen, Cavit Can
Keywords
Related Articles
- EP ID EP226741
- DOI 10.4274/uob.566
- Views 97
- Downloads 0
Tamsulosin Can Improve Lower Urinary Tract Symptoms in Patients Under Active Surveillance Due to Low Risk Prostate Cancer: Prospective Controlled Study
Objective: We aimed to evaluate the efficacy of tamsulosin in the treatment of lower urinary tract symptoms (LUTS) in patients under active surveillance (AS) for low-risk prostate cancer (Pca). Materials and Methods: Pat...
The Importance of Multiparametric Magnetic Resonance Imaging on Prostate Cancer Diagnosis
Objective: In recent years, prostate biopsy under multiparametric magnetic resonance (MPMR) imaging gradually increasing due to inability of transrectal ultrasonography (TRUS) for the detection of suspicious areas about...
Synchronous and Metachronous Secondary Tumors of Bladder Cancer Patients
The improvements in cancer treatment prolonged survival in patients. Despite this survival benefit, chemotherapies, radiotherapies or combination therapies, and continuing exposure to the same carcinogenic agents may lea...
Rare Benign and Uncertain Malignant Potential Tumors of Bladder: Review of the Literature
The most common primary bladder cancer are transitional cell (urothelial) carcinomas. However, there are several uncommon but significant bladder lesions that must be differentiated from urothelial carcinomas. These blad...
A Rare Presentation of Germ Cell Neoplasia: Persistant Müllerian Duct Syndrome
Persistent Müllerian duct syndrome is a rare form of pseudohermaphroditism. This article is made of two case reports showing malignant transformation. The first case was a 36-year-old male who presented with infertility....