The Relationship between Candida Infections and Atherosclerotic Heart Disease
Journal Title: International Journal of Multidisciplinary Research and Analysis - Year 2024, Vol 7, Issue 07
Abstract
Background: The purpose of this investigation is to determine whether or not fungus belonging to the genus Candida can be found within atherosclerotic plaques and to examine various immunological and biochemical indices in patients with particular cardiac conditions who also harbour Candida spp. Specifically, here's what to do and how to do it: In order to determine if fungi were present in an atherosclerotic plaque, a specific test was performed. Method: Twenty autopsies revealed a total of 61 atherosclerotic plaques. In addition, 41 persons with atherosclerosis had their blood tested for TNF-α and IgG and IgM antibodies to Candida spp. There were a wide range of ages represented in this group, from 34 to 85 years old, with 28 men and 13 women. Results: The results showed that fungal species belonging to the genus Candida were present in 24.9% (10/41) of atherosclerotic plaques. Candida krusei and C. dubliniensis were the most common types of Candida identified, while occasionally C. tropicalis and C. albicans were discovered. None of the 41 patients tested positive for IgM, although 30 of them (73.1% of the total) did test positive for IgG. There were fewer IgG-negative patients (n=6) with TNF-α than IgG-positive patients (n=11), although the TNF-α levels in the former were significantly greater than those in the latter (511.7pg/ml, p <0.05). It was shown that the discrepancies between ASAT and ALT levels were much larger in patients who tested positive for Candida spp but negative for TNF-α. Conclusion: Candida fungus may contribute to atherosclerosis by inducing inflammation in the lining of blood vessels.
Authors and Affiliations
Alyaa M. Ali, Anwar Shaqi Ajil
Keywords
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- EP ID EP741197
- DOI 10.47191/ijmra/v7-i07-58
- Views 11
- Downloads 0
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