THE RELATIONSHIP BETWEEN CLINICALLY MANIFEST GASTRODUDENAL DISEASE AND THE GENOTYPE OF THE ASSOCIATED HELICOBACTER PYLORI ORGANISM
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 10
Abstract
Infection with H. pylori has been associated with gastroduodenal diseases such as gastritis, gastric ulcer, duodenal ulcer, gastric cancer and mucosa- associated lymphoid tissue lymphoma (MALT lymphoma). The aim of this study was to detect the relationship between clinically manifest gastroduodenal disease and the genotype of the associated H. pylori organism. The study was conducted on 20 control subjects and 100 patients suffering from upper gastro-intestinal symptoms in the form of dyspepsia, epigastric pain, vomiting, heartburn, hematemesis and melena in which infection with H. pylori was detected by monoclonal antibody based H. pylori stool antigen test. Upper gastrointestinal tract (GIT) endoscopy was performed in all subjects as well as samples from gastric antral mucosa were obtained to detect H.pylori by rapid urease test, Polymerase chain reaction (PCR) for detection of H.pylori strain and the presence or absence of its virulence factors. Results showed that CagA and VacA are two virulence factors that can affect the clinical outcome of H.pylori and there was a significant positive association between the presence of CagA+ve strains and gastroduodenal diseases. VacA s1 genotype was associated significantly with gastroduodenal diseases but VacA m1 allele showed insignificant association.
Authors and Affiliations
Eman Zaki Azzam
Keywords
Related Articles
- EP ID EP629086
- DOI -
- Views 159
- Downloads 0
U-LFABP AS A PREDICTIVE MARKER FOR PROGNOSIS OF DIABETIC KIDNEY DISEASE IN EGYPTIAN PATIENTS
This study was aimed to evaluate the level of urinary liver-type fatty acid binding protein (u-LFABP) as a marker of diabetic kidney disease and to study its correlation with other kidney parameters in Egyptian patients...
COMPARISON OF EFFICACY AND SAFETY OF TWO ARTIFICIAL TEARS IN PATIENTS WITH MILD TO MODERATE DRY EYE SYMPTOMS: A RANDOMIZED, PARALLEL STUDY
Purpose: Artificial tears are commonly used for symptomatic treatment of dry eye disease (DED). We compared the efficacy and safety of two preservative-free lubricant eye drops; Osmodrops (carboxymethylcellulose 0.5%, gl...
“QUALITY PREPRATORY WORK: THE BASIC NEED OF ANALYSIS”.
Quality is compliance to best known standards, processes and specifications. Although analysis of sample is frequently carried out by using sophisticated instruments, the importance of basic laboratory skills cannot be o...
EFFECTIVENESS OF POWER POINT ASSISTED TEACHING ON ENVIRONMENTAL HEALTH AMONG CHILDREN IN SELECTED UPPER PRIMARY SCHOOLS IN GUNTUR, ANDHRA PRADESH
Introduction: Environment is one of the determinants of health which predisposes children to various agents and may cause health problems. According to WHO 24% of the global disease burden and mortality in children were...
CKAP4 PROTEIN MAY BE A NOVEL EARLY SERO-DIAGNOSTIC MARKER FOR LUNG CANCER
Lung cancer is the second most common cancer in both sexes. It is present in advanced stages hence has high mortality rates. Many patients when come for checkup in clinics are already in advanced stages of lung cancer. T...