THE RELATIONSHIP BETWEEN CLINICALLY MANIFEST GASTRODUDENAL DISEASE AND THE GENOTYPE OF THE ASSOCIATED HELICOBACTER PYLORI ORGANISM
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 10
Abstract
Infection with H. pylori has been associated with gastroduodenal diseases such as gastritis, gastric ulcer, duodenal ulcer, gastric cancer and mucosa- associated lymphoid tissue lymphoma (MALT lymphoma). The aim of this study was to detect the relationship between clinically manifest gastroduodenal disease and the genotype of the associated H. pylori organism. The study was conducted on 20 control subjects and 100 patients suffering from upper gastro-intestinal symptoms in the form of dyspepsia, epigastric pain, vomiting, heartburn, hematemesis and melena in which infection with H. pylori was detected by monoclonal antibody based H. pylori stool antigen test. Upper gastrointestinal tract (GIT) endoscopy was performed in all subjects as well as samples from gastric antral mucosa were obtained to detect H.pylori by rapid urease test, Polymerase chain reaction (PCR) for detection of H.pylori strain and the presence or absence of its virulence factors. Results showed that CagA and VacA are two virulence factors that can affect the clinical outcome of H.pylori and there was a significant positive association between the presence of CagA+ve strains and gastroduodenal diseases. VacA s1 genotype was associated significantly with gastroduodenal diseases but VacA m1 allele showed insignificant association.
Authors and Affiliations
Eman Zaki Azzam
Keywords
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