The Relationship between Graft Function and Liver Function after Kidney Transplantation: A Retrospective Cohort Study
Journal Title: Translational Research in Urology - Year 2019, Vol 1, Issue 2
Abstract
Introduction After kidney transplantation, several factors should be checked to predict the risk of rejection. Liver enzymes are such predicting factors so liver function test abnormalities (LFTA) can consider the rejection possibility in kidney transplant recipients (KTR). Methods Through a retrospective cohort study, 659 KTR were studied. The source of all grafts was from deceased donors. Amongst these cases, 67 patients showed a significant rise in creatinine as the rejection indication. Several liver indexes like alanine transaminase (ALT), aspartate transaminase (AST), direct bilirubin (Bil D), total bilirubin (Bil T), and liver ultrasound reports, gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), prothrombin time (PT) INR in addition to creatinine were examined for three-six post-transplant in KTR. Results Our study exposed that liver functional tests regularly had considerable statistical differences between KTR with creatinine increase and with no creatinine increase. Despite these differences between the two groups AST, ALT and ALP serum levels were still within the normal range in both groups. The same result was seen over Bil D and Bil T. Conclusions Liver function test abnormalities can not adequately predict the rejection. Some other elements should be taken into consideration like inflammation factors like erythrocyte sedimentation rate (ESR or sed rate), and C-reactive protein (CRP).
Authors and Affiliations
Seyed Mohammad Kazem Aghamir; Raika Jamali; Seyed Saeed Tamehri Zadeh; Alireza Khajavi; Fatemeh Khatami; Gholamreza Pourmand; Sanaz Dehghani
Keywords
Related Articles
- EP ID EP704277
- DOI 10.22034/TRU.2020.239483.1027
- Views 104
- Downloads 0
Two New Techniques for Management of Non-Deflating Foley Catheters in Men
Introduction: Implicating two new techniques for removal of Foley catheters with non-deflating balloons. Methods: Thirty-two male patients with non-deflating Foley catheters were managed by cutting the balloon channel a...
Effect of Modified Vacuum in Patients with Peyronie’s Disease and Erectile Dysfunction
Introduction Peyronie's disease (PD) is a penile disease that is characterized by penile pain, curvature, shortening, and plaque in the penis which usually ends up in erectile dysfunction (ED). This study is to assess t...
Therapeutic Efficacy of Potassium Citrate for Treating Less Than 10-Millimeter Renal Stones
Introduction: To assess the therapeutic efficacy of potassium citrate in the nonsurgical management of renal stones we run this research. The prophylactic effects of Potassium Citrate over renal stone formation have been...
Complete Renal Duplication with Dysplastic Lower Moiety: A Case Report
Introduction Ureter duplication is a common anomaly of the urinary tract in which both ureters drain one kidney. In bipolar renal duplication, the Meyer-Weigert-Rule describes the duplex ureters draining pattern. Owing...
Short term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis
Introduction: The purpose of the current meta-analysis was to determine the short-term and long-term graft survival and patient survival from the deceased donors, and determine the prognostic factors. Methods: PubMed, S...