THE RELATIONSHIP BETWEEN OXIDATIVE STRESS AND HIGH SENSITIVE C-REACTIVE PROTEIN IN PREECLAMPSIA
Journal Title: International Journal of Basic and Applied Physiology - Year 2014, Vol 3, Issue 1
Abstract
Background & Objectives: Preeclampsia, being most common medical complication of pregnancy requires early diagnosis and intervention. The aim of present study is to measure and correlate serum MDA level with HS-CRP level in preeclampsia.Methods: The present study involves 200 subjects in the age group of 20 to 35 years primigravida, all in their third trimester, recruited from preeclampsia ward and OPD of Mahila Chikitsalaya, Sanganeri gate, Jaipur (Rajasthan). Out of total 200 subjects, 100 were preeclampsia women and 100 were normotensive pregnant women. Data were statistically analyzed by “z” test for comparison of mean and Karl Pearson coefficient of correlation to quantify the association between the variables. Results: The levels of serum MDA (nmol/ml) and HS-CRP (mg/l) were significantly elevated (p<0.05) in preeclampsia women (4.97±1.00 and 1.18±0.43) when compared to normotensive pregnant women (2.43±0.51 and 0.66±0.31), respectively. Moreover, in preeclampsia women, a significant positive correlation (r=0.732, p<0.05) between serum MDA and HS-CRP was observed as compared to normotensive pregnant women (r=0.160; p>0.05). Interpretation & Conclusion: Elevated serum MDA and HS-CRP in preeclampsia women compared with normal pregnant women suggests that oxidative stress in preeclampsia is associated with increased inflammatory responses.
Authors and Affiliations
Rohita Bharadwaj, Dr. Keerti Mathur, Dr. Manisha Sankhla, Dr. Anuradha Yadav, Dr. Deepak Sharma
Keywords
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