The Relationship Between Serum Vitamin D (25(OH)D3), C-Peptide, and Interleukin-2 Level in Children with Type 1 Diabetes Mellitus
Journal Title: Turkish Journal of Immunology - Year 2018, Vol 6, Issue 1
Abstract
Introduction: Vitamin D is very important for Type 1 diabetes mellitus (T1 DM) pathogenesis, and plays major role in the regulation of pancreatic beta cells. However, serum vitamin D (25(OH)D3) level related to inflammatory condition in T1 DM has not been sufficiently investigated. Therefore, we aimed to investigate the relationship between serum vitamin D (25(OH)D3), C-Peptide, and Interleukin-2 levels in children with T1 DM. Material and Methods: Blood samples from 20 subjects of T1 DM patients and healthy patients were collected, and analyzed. Serum level of vitamin D (25(OH)D3), C-Peptide, and Interleukin-2 between two groups were measured by using Indirect ELISA. Results: Serum vitamin D (25(OH)D3), C-Peptide, and Interleukin-2 level between both groups were significantly different (p<0.001). It was shown that serum vitamin D (25(OH)D3) and C-Peptide level had significant positive correlation, while serum C-Peptide and Interleukin-2 level had significant negative correlation (p=0.002; r=-0.658). Serum vitamin D (25(OH)D3) and Interleukin-2 had also significant negative correlation (p<0.001; r=-0.753). Discussion: Serum vitamin D (25(OH)D3) level is related to inflammatory condition in T1 DM. Low level of serum vitamin D (25(OH)D3) in T1 DM patient tends to increase the level of Inteleukin-2, and it is highly correlated with pancreatic beta cells’ impairment, which is marked by low C-Peptide level and high Inteleukin-2 level. Keywords: C-Peptide, interleukin-2, T1 DM, vitamin D (25(OH)D3)
Authors and Affiliations
Harjoedi Adji Tjahjono, Vivi Ratnasari, Edi Widjajanto, Andreas Budi Wijaya
Keywords
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- EP ID EP450671
- DOI 10.25002/tji.2018.722
- Views 77
- Downloads 0
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