The Relationship Between the BRAFV600E Mutation in Differentiated Thyroid Cancer and Clinicopathologic Factors in Vietnam
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 9, Issue 1
Abstract
Objective: Among more than 40 mutations identified in the BRAF gene, the BRAF T1799A (V600E) point mutation is the most common and accounts for more than 90% of all the mutations found in the BRAF gene. It has been found to occur frequently in thyroid cancer. While some reports suggest the BRAF V600E mutation is associated with poor prognosis and recurrence or iodine uptake resistance, this remains a controversial issue. The aim of study was to: 1) determine the status of BRAF mutation in differentiated thyroid cancer in Bach Mai hospital; 2) evaluate the association of the BRAF mutation with clinicopathological parameters. Patients and Methods: Retrospective analysis of the BRAF V600E mutation in differentiated thyroid cancer in 198 patients from November 2015 to March 2017 at Bach Mai hospital using BRAF 600/601 Strip Assay® (ViennaLab, Austria). The results were correlated with clinicopathological factors. Results: The BRAF V600E mutation was detected in 150 cases (75.8%). BRAF mutation was found in 69/92 (75%) patients having metastasis. Mutation was found in distant metastasis, lymph node metastasis and in both distant-lymph node metastasis: 63/84 (75%), 9/13 (69.2%) and 3/5 (60%), respectively. Among differentiated thyroid cancer, BRAF mutation was detected in follicular-papillary thyroid cancer (80%), papillary thyroid cancer (76.6%) and in follicular thyroid cancer (40%). There was no significant correlation between the presence of BRAF mutation and clinicopathological factors. Conclusions: The BRAF mutation rate in thyroid cancer patients is high, especially for follicular-derived papillary and papillary thyroid cancer. The lack of a statistically significant association of BRAF and clinical characteristics indicates the need of conducting research with larger sample sizes in the future.Thyroid cancer shows the fastest rising incidence among all major human cancers, currently with 44,670 new cases in the United State. Differentiated thyroid cancer is the most common cancer of the endocrine system and the papillary thyroid cancer is the most common type, followed by follicular thyroid carcinoma. In recent decades, the incidence of this type of cancer has increased in Vietnam. According to GLOBOCAN 2012, the prevalence rate is 2.5/100000 people, mortality rate is 1.3/100000 people per year. Most thyroid cancers generally have a good prognosis after appropriate treatment including surgical procedure and radioiodine therapy [1]. However, the recurrence rate of differentiated thyroid cancer increased up to 30%, and the cancer death rate was 8% after initial treatment at 30 years of follow-up. Studies in the world have shown that the primary cause of recurrence and metastasis in patients treated radioiodine therapy are low absorption and poor iodine intake (Table 1) [1,4].
Authors and Affiliations
Mai Trong Khoa, Pham Cam Phuong, Nguyen Thanh Trung, Nguyen Tien Lung, Nguyen Thuan Loi, Tran Dinh Ha
Keywords
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- EP ID EP591719
- DOI 10.26717/BJSTR.2018.09.001748
- Views 118
- Downloads 0
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