The Relationship of Birth Weight, Feeding and Gestational Age with Serum Copper and Zinc in Premature Neonates
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 5
Abstract
ABSTRACT Introduction: Zinc and copper have a main role as nutrients in the growth and development of neonates. Aim: To evaluate the relationship of birth weight, feeding, and Gestational Age (GA) with serum copper and zinc in preterm neonates. Materials and Methods: This cross-sectional study has evaluated 107 preterm infants with Birth Weight (BWT) less than 2500 g that were hospitalised in neonatal intensive care unit for at least 10 days from January 2014 to March 2016 in Shiraz, Iran. Zinc and copper serum levels were compared in very low BWT (≤1500 g) and low BWT (1500-2500 g) in newborns and were investigated in regard to the type of nutrition, BWT, and GA. Zinc and copper levels were estimated using Flame-Atomic Absorption Spectrophotometry. Multiple linear regression analysis and Pearson’s correlation coefficient (r) test were used. Results: The mean plasma zinc levels in low BWT and very low BWT groups were 83.9±17.1 μg/dL and 48.2±10.4 μg/dL, respectively (p<0.001). The mean serum copper levels in low BWT and very low BWT groups were 70.48±15.4 μg/dL and 82.7±12.03 μg/dL respectively (p<0.001). There was a significant inverse correlation of serum copper with BWT (r=-0.525, p-value<0.001) and GA (r=-0.572, p-value<0.001). However, there was a positive correlation of the zinc level with BWT (r=0.758, p=0.001) and GA (r=0.741, p-value=0.001). Conclusion: Serum zinc is directly related to GA and LBW. Consequently, supplementation with zinc in premature neonates and LBW is necessary, but not copper.
Authors and Affiliations
Omid Reza Zekavat, Alireza Sahraian, Somayeh Esmaili, Sezaneh Haghpanah, Susan Rabie, Farzaneh Alipour, Reza Bahrami, Nader Shakibazad
Keywords
Related Articles
- EP ID EP583432
- DOI 10.7860/JCDR/2019/40236.12846
- Views 126
- Downloads 0
Pichia anomala, A Rare Cause of Nosocomial Fungal Sepsis in Newborn. Is Empirical Use of Third Generation Cephalosporin to Blame?
ABSTRACT Traditionally, Candida albicans is known to be the major cause of nosocomial fungal sepsis in neonates. However, there has been increased detection of various other emerging pathogenic yeasts like Pichia anomala...
A Case of Hyperargininaemia Presenting at Unusually Low Age
Arginase or ARG1 gene deficiency is a Type V Urea Cycle Disorder (UCD) (catalysing the fifth reaction of urea cycle), associated with hyperammonaemia. Here, we discuss a rare case of a 13-month-old female, having Severe...
Trichoadenoma of Nikolowski- A Rare Tumour with Unusual Presentation Over Vulva
Trichoadenoma is a rare benign, slowly growing, cutaneous tumour of the hair follicle first described by Nikolowski in 1958. It presents as a non-specific nodule over the face or buttocks. However, unusual sites such as...
Practice of Intravenous to Oral Conversion of Antibiotics and its Influence on Length of Stay at a Tertiary Care Hospital: A Prospective Study
ABSTRACT Introduction: Several studies have demonstrated the efficacy and safety of switching from intravenous to oral antibiotics in clinically stable patients. Early switch from Intravenous (IV) to Per Oral (PO) could...
Validity of Simplified Ankylosing Spondylitis Disease Activity Scores (SASDAS) in Indian Ankylosing Spondylitis Patients
Introduction: Ankylosing Spondylitis Disease Activity Score (ASDAS) is a complex score for monitoring disease activity in Ankylosing Spondylitis (AS). Aim: To develop a simplified version of the ASDAS. Materials and Meth...