The Relationship Of Free ß-hCG, PAPP-A, AFP, ß-hCG, UE3 In Pregnancy With Fac, 50 Gram Glucose Screening Test And Birth Weight
Journal Title: Acta Medica Ruha - Year 2023, Vol 1, Issue 3
Abstract
Objective: It is possible to improve the quality of health and care and to minimize high-costmedical expenses by closely monitoring the complications in infants born with abnormal fetal birthweights. Within the scope of this research, we aimed to elucidate the relationship between first andsecond-trimester screening tests plasma proteins and 50 g glucose tolerance test values used ingestational diabetes screening with estimated birth weight.Method: A total of 831 cases with regular antenatal follow-ups in Ankara AtatürkTraining and Research Hospital, Gynecology, and Obstetrics Clinic were enrolled. The first-trimester fetal aneuploidy screening determined PAPP-A and free-β-hCG values. The second-trimester triple test determined Alpha-feto protein, hCG, and unconjugated estriol values. Fastingblood glucose was measured at the first visit, and a 50 g oral glucose tolerance test (OGTT) wasperformed between 24 –28 weeks of gestation. Pregnancies continued without complications andwho gave birth at term (gestational age 37+0 weeks) were included in the study.Results: When the relationship between the hormonal values used in the first and second-trimesteraneuploidy screening and the 50 gr OGTT (mg/dl) values are examined, no correlation betweenfree-beta-hCG and 50 g OGTT (mg/dl) (r= -0.055, p= 0.128). Maternal fasting blood glucose levels(r= -0.055, p= 0.131) did not reveal any relationship with first and second-trimester aneuploidyscreening. PAPP-A (r= -0.011, p= 0.765), AFP (r= -0.033, p= 0.369), uE3 (r= 0.035, p= 0.340).(Figure 14), and hCG values (r= -0.051, p= 0.164), also did not present correlation with maternalfasting blood glucose levels.Conclusion:According to the results ofour study, no relationship was found between the hormonesused in the first trimester (PAPP-A and free-beta-hCG) and second-trimester (AFP, hCG, and uE3)aneuploidy screening and 50 g OGTT, maternal plasma blood glucose level and birth weight.
Authors and Affiliations
Saniye Gezegen
Keywords
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- EP ID EP722144
- DOI 10.5281/zenodo.8262574
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