The Relationship of Hemogram Parameters and Night Desaturation in Patients Diagnosed with Obstructive Sleep Apnea Syndrome
Journal Title: Türk Uyku Tıbbı Dergisi - Year 2018, Vol 5, Issue 3
Abstract
Objective: Obstructive Sleep Apnea syndrome (OSAS) is a disease characterized by recurrent complete (apnea) or partial (hypopnea) upper respiratory tract obstructions episodes during sleep and often a decrease in blood oxygen saturation. Night hypoxias and sympathetic activity increase of arousals in OSAS are thought to stimulate that endothelial dysfunction and hypercoagulability. Materials and Methods: In this study, it was aimed to evaluate the relationship between the severity of the disease and the night hypoxia severity with hemogram parameters in patients diagnosed with OSAS who examined in our clinics. A total of 94 cases were included in the study, including 24 controls, 24 mild, 23 moderate, and 23 severe OSAS. Results: The mean and minimum oxygen saturation values in polisomnography with the number of neutrophils and neutrophil/lymphocyte (N/L) ratio were negatively correlated in the mild and severe OSAS groups. A negative correlation was observed between erythrocyte distribution width (EDW) and, mean oxygen saturation and minimum oxygen saturation in moderate and severe OSAS. When the mean and minimum oxygen saturation with regression analysis of EDW and N/L ratio were examined in each three groups; the 1 unit decrease in the minimum oxygen saturation increases the N/L ratio by 0.5-fold (p=0.02) in the mild OSAS, 0.5-fold (p=0.01) in the severe OSAS and it increases the EDW by ratio 0.5-fold (p=0.02) in the moderate OSAS. The 1 unit decrease in the mean oxygen saturation increases the N/L ratio by 0.4-fold (p=0.04) and the EDW by 0.8-fold (p=0.001) in the severe OSAS. Conclusion: As long as the OSAS severity increases, it is determined that the hematocrit values of patients increasing. However, as patients’ sleep desaturation increase, we can see that EDW, the number of neutrophils, and N/L ratio also increasing. This situation suggests that the local inflammation caused by both mechanical stress and ischemia-reperfusion cycles in the respiratory tract in OSAS is a consequence of spillage into the systemic circulation.
Authors and Affiliations
Zahide Alaçam, Sibel Pekcan, Beyza Akdağ, Hande Şenol
Keywords
Related Articles
- EP ID EP421926
- DOI 10.4274/jtsm.40469
- Views 114
- Downloads 0
Comorbidity of Obstructive Sleep Apnea Syndrome, Cronic Obstructive Lung Disease and Asthma Chronic Airway Diseases and Sleep Apnea
Objective: Sleep disorders are conditions that often interfere with chronic airway diseases and affecting both the course of illness and the quality of life. Obstructive sleep apnea syndrome (OSAS) is the most common gro...
Chronic Intermittent Hypoxemia in Patients with Obstuctive Sleep Apnea Syndrome Causes Reduction of Peripheral Nerve Motor Fibers (Unit Number)
Objective: Obstructive Sleep Apnea syndrome (OSAS) is a chronic intermittent hypoxic process. In this study, we aimed to investigate electrophysiologically the changes in number of skeletal muscle motor unit due to chron...
Restless Legs Syndrome Treatments in Adults: Practice Guideline Summary of American Academy of Neurology
Restless legs syndrome is a common neurological disorder characterized by intense restlessness, relaxed with action, disturbance in the limbs and unpleasant sensations. Treatment should be considered if restless legs syn...
Association with Asthma and Restless Legs Syndrome and Sleep Quality
Objective: We aimed to evaluate the frequency and severity of restless legs syndrome in patients with asthma and the effect of the disease on sleep quality. Materials and Methods: Forty-three patients followed by asthma...
Editorial
.