The relationship of macrophage migration inhibitory factor with clinical and anamnestic parameters in patients with ST-segment elevation myocardial infarction
Journal Title: Український терапевтичний журнал - Year 2019, Vol 0, Issue 1
Abstract
Objective — to investigate the association between levels of the macrophage migration inhibitory factor (MIF) and the clinical and anamnestic parameters in patients with ST segment elevation myocardial infarction (STEMI) and to determine the factors, affecting this relationship. Materials and methods. The study involved 73 patients with previous confirmed STEMI and successful recovery of blood flow (TIMI-III). The mean patients’ age was (58.37 ± 10.34) years. Clinical, anamnestic and biochemical indicators were determined. The level of MIF was studied using the enzyme linked immunoassay method (RayBio® Human MIF ELISA KIT, USA). The general group of patients was divided by the median MIF level: the first group consisted of patients with low or moderate MIF (≤ 2582.80 ng/ml), n = 36, the second group consisted pf patients with high levels of this cytokine (> 2582.80 ng/ml), n = 37. Mono- and multivariate regression analysis was carried out to identify factors, that mostly significantly affected the MIF levels. Results and discussion. The comparison of median values of the MIF levels in STEMI patients revealed the significant increase in MIF levels vs the control group (2582.80 [1308.40—4122.20] and (573.75 [397.80—1016.75] ng/ml, p < 0.001), that confirmed activation of the MIF formation because of the index event. Positive correlation was determined between the MIF levels, levels of troponin I (r = 0.33; p = 0.045) and blood leukocytes (r = 0.36; p = 0.039). Anterior myocardial infarction (p = 0.047) and injury of left anterior descending artery (p = 0.016) were detected more frequently in the group of patients with high MIF levels, that indicates its directly connection with the size of the myocardial infarction in combination with significantly higher troponin level. Multivariate and univariate logistic analysis showed the reliable independent association between the anterior localization of the MI and the elevated MIF level (OR = 0.2282, 95 % CI [0.1035—0.7680], p = 0.0133), as well as the presence of stable angina to the index event and the lower level of cytokine (OR = 0.2318, 95 % CI [0.0637—0.8438], p = 0.0266). Conclusions. The macrophage migration inhibitory factor at STEMI is involved in the processes of inflammation and necrosis, its increase indicates the direct relationship with the myocardial infarction extension. The presence of stable angina prior the myocardial infarction promotes the pre-conditioning effect and a lower degree of damage, and proportionally lower MIF levels.
Authors and Affiliations
O. V. Petyunina, M. P. Kopytsya, A. V. Kobets
Keywords
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- EP ID EP583470
- DOI 10.30978/UTJ2019-1-50
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