The research progress of CAR-T cell immunotherapy for gastric cancer
Journal Title: Biomedical Transformation - Year 2021, Vol 2, Issue 1
Abstract
Gastric cancer (GC) is the third leading cause of cancer mortality in the world. Unfortunately, traditional treatments have limited efficacy. Recent research shows that CAR-T immunotherapy is a promising treatment for GC. Using genetically engineered T cells designed to target a tumor specific antigen, researchers are able to harness the natural anti-tumor activity of T cells. Therefore, it is essential to choose specific antigens that are highly expressed on tumor cells but not on healthy cells. In this review, we present an overview of the most important antigens for CAR-T therapy in the context of GC. A number of clinical studies point to the following as important markers: NKG2D, EpCAM, CLDN, MSLN, FOLR1, HER2, MUC1. Although these markers have been met with some success, the search for new and improved targets continues.
Authors and Affiliations
Wang Yan, Qin Long, Jiao Zuoyi
Keywords
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- EP ID EP767195
- DOI 10.12287/j.issn.2096-8965.20210109
- Views 22
- Downloads 0
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