The research progress on the mechanism of icariin accelerating fracture healing
Journal Title: Biomedical Transformation - Year 2021, Vol 2, Issue 1
Abstract
In recent years, international and domestic academics have made a series of studies on the mechanism of icariin which is the main effective component of Herba Epimedii, to accelerate fracture healing. The current research results show that the mechanism of icariin accelerating fracture healing is to promote the migration and homing of BMSCs and ASCs by activating Wnts, BMP, MAPK, ER and other related signal pathways, so as to carry out osteogenic differentiation into osteoblasts. At the same time, it can promote the maturation and mineralization of osteoblasts to form callus, and inhibit the bone resorption activity of osteoclasts. This article reviews the mechanism of icariin in accelerating fracture healing from the aspects of its effects on related cells and vascular remodeling, so as to provide reference for the follow-up research.
Authors and Affiliations
Hou Xuefeng, Gao Yuhai, Bai Xin, Chen Keming
Keywords
Related Articles
- EP ID EP767200
- DOI 10.12287/j.issn.2096-8965.20210113
- Views 10
- Downloads 0
Functions and regenerative applications of adult human airway epithelial basal cells
Basal cells are the major cell type of the adult airway epithelium, expressing the molecular markers P63 and KRT5, and possessing tissue stem cell properties such as self-renewal capacity and multidirectional differentia...
Analysis of research progress on time factors in traumatic brain injury
Traumatic Brain Injury (TBI) has garnered increasing attention due to its long-term effects on patients and the rising incidence of brain injuries in emergency department visits in recent years. The timing of pharmacolog...
Single-cell transcriptomics technology and its application in limb regeneration research
Salamanders have a strong ability to regenerate limbs, while this potential is progressively declined in frogs during development. With evolution, adults of humans and other mammals completely lose the ability to regener...
Analysis and insights on the models of technology transfer in universities and hospitals in Asia region
Technology transfer is a key driver of innovation and development in biomedicine and health worldwide. In the Asia region, countries such as Singapore, Japan, and Israel have achieved significant success in this field, w...
Research progress and prospects of bone defect therapy using stem cell-derived exosomes
Bone regeneration is a sophisticated, precisely controlled physiological process. In addition to bone metabolism balance under normal conditions, bone regeneration occurs also in bone repair process following bone damage...