The Results of combinet treatment patients with olfactory neuroblastoma in material of Cancer Center in Warsaw
Journal Title: Otolaryngologia Polska - Year 2011, Vol 65, Issue 5
Abstract
SUMMARY The results of combined treatment patients with olfactory neuroblastoma in material of Cancer Center in Warsaw Aim: The analysis of the results of combined treatment patients with olfactory neuroblastoma in material of Cancer Center in Warsaw. Material: Authors present material of 27 cases olfactory neuroblastoma treated in Cancer Center of Warsaw from 1965 to 2008. The median age was 44 years (range 10-74). The median observation was 72 months (range 2-235).The tumors were seen in 15 women and 12 men. According to Kadish staging there were one A, eight B, and seventeen C stage tumor. The pa-tients in stage A and B was treated by surgery and radiotherapy (mean dose in whole material was 57.15 Gy range 44-70). Five patients in stage C was treated by surgery, radiotherapy and adjuvant chemotherapy. Five patients were treated by neoadjuvant chemotherapy and radiotherapy. Six patients underwent surgery and radiotherapy. One patient was died during adjuvant chemotherapy. One patient in stage B had local recurrence, one local recur-rence and metastases and one had only metastases. In stage C 4 patients was died because of metastases, one had local recurrence and, 3 was died because of other reasons. Patients who was failed, underwent surgery, chemotherapy or radiotherapy, it was dependent of clinical situation. A complete regression was seen in 100% patients in early stages (A and B) and 82% patients in stage C. The 5-year local progression-free survival rate was 91% in early stages and 60% in stage C. The LPFS in whole group was 66.7%. The 5-year disease-free survival rate was 91% in early stages, 46% in stage C. The DSF rate in whole group was 44.4%. The 5-year overall survival rate was 80% in stages A and B, 41.2% in stage C. The OS in whole group was 55.6%. The 5-year survival rate was 20% for patients who had recurrence and/or metastases. Conclusion: A combination of surgery and radiotherapy appears to be ad-equate treatment for early stages (A and B) olfactory neuroblastoma. There are stil) no clear protocols of treatment patients in stage C.
Authors and Affiliations
Andrzej Jarząbski, Dorota Kiprian, Zbigniew Szutkowski, Wojciech Michalski
Keywords
Related Articles
- EP ID EP52372
- DOI -
- Views 87
- Downloads 0
Otologiczne objawy ziarniniaka Wegenera
Wegeners granulomatosis is a necrotizing granulomatous vasculitis with multisystemic involvement. We present two cases of Wegener's presenting with otological manifestations as the first symptom. These symptoms are subtl...
Late phoniatric results of treatment of patients with cleft palate operated on by one surgeon
Introduction. The aim of the study was the assessment of the late speech results the cleft palate patients. Material and methodic. From January 1987 to December 1996 the first author performed 268 cleft palate surgeries....
Usefulness of snoreplasty in the treatment of simple snoring and mild obstructive sleep apnea/hypopnea syndrome – Preliminary report
The aim of the study: To assess the effectiveness of sodium tetradecyl sulfate injection in the region of the soft palate to treat primary snoring and mild obstructive sleep apnea/hypopnea syndrome. Sodium tetradecyl sul...
Efferent suppression test – sensitivity and specifi city
Introduction. The amplitude of click evoked otoacoustic emissions can be suppressed (reduced) with contralateral acoustic stimulation (CAS). This is thought to be due to the inhibitory control that the medial efferent au...
Consenting Practice of ENT Trainees: To What Extent Is Trainee Involvement Disclosed?
Aim – To assess to what extent ENT trainees disclose their involvement in operations to their patients when obtaining consent.Background – It is not clear how the trainees are conducting the consenting process, although...