The Results of combinet treatment patients with olfactory neuroblastoma in material of Cancer Center in Warsaw
Journal Title: Otolaryngologia Polska - Year 2011, Vol 65, Issue 5
Abstract
SUMMARY The results of combined treatment patients with olfactory neuroblastoma in material of Cancer Center in Warsaw Aim: The analysis of the results of combined treatment patients with olfactory neuroblastoma in material of Cancer Center in Warsaw. Material: Authors present material of 27 cases olfactory neuroblastoma treated in Cancer Center of Warsaw from 1965 to 2008. The median age was 44 years (range 10-74). The median observation was 72 months (range 2-235).The tumors were seen in 15 women and 12 men. According to Kadish staging there were one A, eight B, and seventeen C stage tumor. The pa-tients in stage A and B was treated by surgery and radiotherapy (mean dose in whole material was 57.15 Gy range 44-70). Five patients in stage C was treated by surgery, radiotherapy and adjuvant chemotherapy. Five patients were treated by neoadjuvant chemotherapy and radiotherapy. Six patients underwent surgery and radiotherapy. One patient was died during adjuvant chemotherapy. One patient in stage B had local recurrence, one local recur-rence and metastases and one had only metastases. In stage C 4 patients was died because of metastases, one had local recurrence and, 3 was died because of other reasons. Patients who was failed, underwent surgery, chemotherapy or radiotherapy, it was dependent of clinical situation. A complete regression was seen in 100% patients in early stages (A and B) and 82% patients in stage C. The 5-year local progression-free survival rate was 91% in early stages and 60% in stage C. The LPFS in whole group was 66.7%. The 5-year disease-free survival rate was 91% in early stages, 46% in stage C. The DSF rate in whole group was 44.4%. The 5-year overall survival rate was 80% in stages A and B, 41.2% in stage C. The OS in whole group was 55.6%. The 5-year survival rate was 20% for patients who had recurrence and/or metastases. Conclusion: A combination of surgery and radiotherapy appears to be ad-equate treatment for early stages (A and B) olfactory neuroblastoma. There are stil) no clear protocols of treatment patients in stage C.
Authors and Affiliations
Andrzej Jarząbski, Dorota Kiprian, Zbigniew Szutkowski, Wojciech Michalski
Keywords
Related Articles
- EP ID EP52372
- DOI -
- Views 102
- Downloads 0
Experiences with treatment of extended laryngo-tracheal stenosis with employment of transversal resection of trachea
The aim of this study is to evaluate the results obtained in Department of Otolaryngology et Oncology with transversal resection of trachea acc. to Pearson technique for postintubation stenosis. Methods. from January 200...
The rare case of metastasis to lumbar part of spinal column from laryngeal cancer
A rare case of distant metastasis to spinal column – lumbar vertebra (L5) – from laryngeal cancer was reported. It must be noted that in 10 % of cases metastases to vertebral column are fi rst symptom of a neoplastic dis...
Evaluation of Fas and FasL expression on peripheral blood in patients with Iaryngesl cancer
SUMMARY The aim of the study was evaluation of Fas and FasL receptors' expression on peripheral blood Iymphocytes in patients with Iaryngeal cancer. The study was conducted in a group of 62 patients with different clinic...
Role of adenotonsillectomy in OSAS children and behavioural disturbance
Aim: The main aim of this study was to assess the presence of behavioural disturbances in child with OSAS before and after adenotonsillectomy (AT). Background: In children adenotonsillar hypertrophy is associated with in...
Results of surgical treatment in patients with sulcus vocalis
Sulcus vocalis is one of the most difficult to treat benign vocal fold pathologies. Ford distinguished three types of sulci: I- superficial, II- vergeture and III- true sulcus vocalis. The aim of the study was to assess...