The results of prospective multicenter study of the effectiveness of amino acid formula in infants with severe atopic dermatitis and allergy to cow’s milk proteins
Journal Title: Здоров`я дитини - Year 2014, Vol 4, Issue 55
Abstract
The article presents the main results of prospective multicenter study of effectiveness of using amino acid formula in diet therapy for the infants with severe atopic dermatitis (AD) and allergy to cow's milk protein (CMP). The study was conducted in 5 centers of Ukraine and included 30 infants with severe atopic dermatitis (EASI score > 18) aged from 29 days to 11 months. 22 patients completed the study. Diet therapy considered administration of amino acid formula containing 100 % free amino acids, for 4 weeks. Evaluation of clinical effectiveness of AD and allergy to CMP diet therapy with amino acid formula was carried out on the 7th, 14th and 28th day after reaching the full daily volume of the formula. Provocative test was performed on the 28th day with extensively hydrolyzed whey protein formula followed with evaluation of immediate and late reactions. Infants with severe AD (EASI score > 18) were characterized by impairment of several organs and systems: in 68 % of cases skin symptoms were associated with the gastrointestinal signs like change in stool frequency (constipation, diarrhea), appearance of pathological admixtures in feces (mucus, blood), vomiting, and others. With administration of amino acid formula significant decrease in severity of skin (98 %) and gastro-intestinal manifestations of food allergy (82 %) were seen. Amino acid formula was well tolerated by children with severe AD and, if needed, it might be used as a therapeutic formula for an exclusive feeding of infants with severe allergies to CMP. Duration of the diet therapy should not be less than 4 weeks. High effectiveness of this formula in infants with AD was proved by parents and doctors.
Authors and Affiliations
S. L. Nyankovskyy, O. G. Shadrin, V. A. Klimenko, D. O. Dobryanskyy, M. S. Iatsula, O. S. Ivakhnenko, S. M. Nedelska, T. V. Kobets, O. M. Ashcheulov, H. A. Haiduchyk, O. P. Paholchuk, O. V. Hostishcheva
Keywords
Related Articles
- EP ID EP311945
- DOI -
- Views 112
- Downloads 0
Lymphatic Drainage — the Basis of Bioregulatory Approach in the Treatment of Childhood Diseases
Children’s bodies are extremely sensitive to the action of various pathogens, toxins, chemicals, as well as mental stresses [1]. In today’s environmental, economic and social conditions, an increased antigenic load has c...
The Use of Linezolid in Children with Malignant Solid Tumors
In recent decades, in the treatment of cancer there has been achieved a significant success not only by the introduction of cancer treatment protocol, but mostly due to the planned combination concomitant treatment of in...
Osteomyelitic Mask of Acute Lymphoblastic Leukemia Onset in a Child
The article describes a clinical case of acute lymphoblastic leukemia in 11-year-old child under a mask of odontogenic osteomyelitis. The peculiarities of this case were difficulties in the differential diagnosis of the...
Involvement of Interleukin 1 Family in the Development of Inflammatory Response in the Infectious Process. 1. General Description of Interleukin 1 Family
The general characteristics of interleukin 1 family is given in the review.
Juvenile systemic scleroderma and ecology (literature review and author’s research)
The paper deals with a literature review and the results of author’s research of ecology role in juvenile systemic sclerosis (SSc). The development of SSc and the rate of its progression in children is closely linked to...