The Retrospective Evaluation of The Local Tumor Control and Adverse Effects of Treatment in Patients Treated Using Cyberknife Stereotactic Radiotherapy in Vestibular Schwannomas
Journal Title: Journal of Academic Research in Medicine - Year 2020, Vol 10, Issue 1
Abstract
Objective: Although the most common tumors of the cerebellopontin angle of the vestibular schwannomas (VS) are benign tumors and are rarely fatal due to their localizations, the symptoms of the disease decreases the quality of life. The aim of the present study was to evaluate the local tumor control, hearing functions, and the adverse effects of treatment of radiotherapy using Cyberknife® device which is a recently popular non-invasive procedure causing minimum toxicity in the neighboring tissues with sharp dose decreases in the treatment of patients with VS particularly in intracranial tumors. Methods: Cyberknife® radiosurgery was administered to 28 patients diagnosed with VS in the present study. The patients were followed-up with routine radiologic screening, audiologic tests, and with the evaluation of the neurologic functions. The study was performed retrospectively, and the data of the patients were obtained from the archive files. Results: CyberKnife® stereotactic radiotherapy was administered to 28 patients diagnosed with VS. The mean follow-up time was 40.25 months. Local control rate was found as 100% in the follow-ups, the rate of protection of hearing in patients with adequate level of hearing was 73.6%, and the protection rates of the facial and trigeminal nerves was found as 100%. No statistically significant difference was detected in the distribution of the age, treatment dose, and tumor sizes in patients in accordance with the deterioration of hearing after treatment. Conformity index (CI), and coverage were found as the predictive factors in the protection of hearing. Conclusion: The investigation of the stereotactic results of VSs in the literature showed that local control and hearing functions were moderately protected, and cranial nerve associated toxicity was found in moderate levels. The treatment parameters of CI and coverage were found as the predictive values in the protection of functional hearing after treatment. Randomized controlled prospective studies in patient groups with longer follow-up periods were required for ultimately determining the reliability of this treatment modality.
Authors and Affiliations
Tanju Berber , Senar Günenç , Ferdi Aksaray , Sevil Çağıran Kılçıksız
Keywords
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