The role of adipocytokines in the development of non-alcoholic fatty liver disease in patients with hypertension and obesity
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 4
Abstract
Background. Incidence of non-alcoholic fatty liver disease (NAFLD) is increasing throughout the world along with epidemic of obesity (OB) and type 2 diabetes mellitus. The purpose of the study was to analyze the levels of leptin, adiponectin and leptin resistance in patients with NAFLD and OB. Materials and methods. The study involved 96 patients with NAFLD. The average age of patients was 53.70 ± 5.34 years. Compensated type 2 diabetes mellitus was diagnosed in 44 individuals. Fifty apparently healthy people matched by age and sex (60 % — women, 40 % — men) were included into the control group. Levels of leptin, adiponectin were studied by enzyme-linked immunosorbent assay. Results. It was found that leptin levels are much higher (1.74–2.39 times; p < 0.001) in women than in men, regardless of the type of NAFLD (steatosis or non-alcoholic steatohepatitis (NASH)) and the degrees of OB. In men with steatohepatosis, the concentration of leptin prevailed over that of men with steatohepatitis — by 25.39 % (pNASH < 0.05). Additionally, in the presence of OB degree III, the content of leptin was higher than in OB degrees I and II, regardless of sex. There was an increase in the rate of leptin resistance by 22.22 % (p < 0.05) in steatosis, and by 46.15 % (p = 0.035) and 42.79 % (p = 0.044), respectively, in patients with NAFLD in general and with OB degree III. On the contrary, the concentration of anti-inflammatory adiponectin in OB degrees II and III was lower than in OB degree I by 5.73 and 5.91 % (p < 0.05). Conclusions. The course of NAFLD is accompanied by disorders in the secretory function of adipose tissue, hyperleptinemia, more severe in women, without a clear dependence of steatosis or NASH and the degree of obesity. OB degrees II and III is associated with lower content of adiponectin (p < 0.05).
Authors and Affiliations
Yu. M. Yarynych
Keywords
Related Articles
- EP ID EP370100
- DOI 10.22141/2224-0721.14.4.2018.140187
- Views 43
- Downloads 0
Morphometric and Biochemical Clusters of Metabolic Syndrome in Type 2 Diabetic Patients at Different Stages of Diabetic Retinopathy
Background. We studied the morphometric and biochemical clusters of metabolic syndrome in patients with type 2 diabetes mellitus (DM) at different stages of diabetic retinopathy (DR). Materials and methods. The study inc...
Diabetes Mellitus Type 2: How to Avoid Errors and to Increase the Effectiveness of Rreatment
The article considers the urgency of the problem of diabetes mellitus incidence (DM) in the world today. It is emphasized that at the present stage of development of diabetology main goal of DM treatment is to achieve bl...
Morphological and Functional Properties of Erythrocytes in Chronic Obstructive Pulmonary Disease Combined with Obesity
During the examination of 61 patients with chronic obstructive pulmonary disease in combination with varying degrees of obesity and without it, it was found that one of the mechanisms of disease progression is a violatio...
Particularities of Arterial Hypertension Depending on the Amount and Distribution of Adipose Tissue in Patients with Type 2 Diabetes Mellitus
The features of arterial hypertension in obese patients with type 2 diabetes mellitus were analysed in the article. For this purpose, 53 patients (out of them 25 men) aged 55.90 ± 2.15 years, with diabetes mellitus type...
Diagnosis and Treatment of Hypophyseal Cushing’s Syndrome
The paper deals with the questions on etiology, pathogenesis and diagnosis of hypophyseal Cushing’s syndrome. There are described the clinical picture of Cushing’s syndrome as well as the conditions associated with hyper...