The role of adipokines and gut hormones in the pathogenesis of obesity, and recent findings for the future treatment of
Journal Title: Scientific Journal of Review - Year 2013, Vol 2, Issue 11
Abstract
Obesity has become one of the leading public health concern.Over one billion people are оverweight or obese and the prevalence of theseconditions is growing constantly. This review presents an overview of theendocrine functions of adipose tissue, the role of gut hormones and theirassociated neuronal networks (the gut-brain axis) in appetite control. Recentstudies have improved our understanding of energy homeostasis by identifyingsophisticated neurohumoral networks that transmit signals between the brain andgut to control food intake. Key adipokines, such as, leptin, adiponectin,interleukin-6, рlasminogen activator inhibitor-1, resistin, tumor necrosisfactor-α, adipsin and acylation stimulating protein, macrophages and monocytechemoattractant protein-1, plasma renin, plasma angiotensin - converting enzymeand angiotensinogen linked with pituitary neuropeptide system began to clarify.Gut hormones, such as, сholecystоkinin, ghrelin, peptide YY, pancreaticpolypeptide, glucagon-like peptide-1, оxyntomodulin, ghrelin, insulin,glucagon, obestatin, amylin аre modulated by acute food ingestion. This articlehighlights some of the recent findings and their implications for the futuretreatment of obesity, but there are currently no effective pharmacologicalinterventions for obesity.
Authors and Affiliations
B. ilkovska| PHO Clinical hospital d-r Trifun Panovski Bitola R.Macedonia., B. Kotevska| Tokuda hospital Sofia R.Bulgaria., D. Labudovic| Department of Medical and Experimental Biochemistry, University School of Medicine, Skopje, Macedonia.
Keywords
Related Articles
- EP ID EP75
- DOI 10.14196/sjr.v2i11.1039
- Views 580
- Downloads 43
Conceptual instrumentation of washing machine for conformity to the Islamic laws of Syarak
The concept of today’s washing machine that uses control technology to clean clothing is based on clothing weight factor proportionately to the amount of water used irrespective of the nature of the contaminants. However...
The significance of engendered indigenous knowledge systems in smallholder animal agriculture in Sub Saharan Africa
The subject of gender and animal agriculture has attracted attention in recent years, primarily from the need to addressing the gender divide and fulfilling the special needs of women in food production. Animal agricul...
Guarantee of woman social security and welfare rights in light of Iran Islamic Republic Constitution
There are a lot of rules mentioned in the constitution law of Iran regarding to women rights. Some of them mention women as just a woman and some refer to them as wife or a mother. These rules in the constitution of law...
Prospects and challenges of increasing the development impact of agricultural research in enhancing food and nutrition s
Increasing the development impact of agricultural research as it relates to promoting food and nutrition security continues to be a major challenge in Sub Saharan Africa. The preceding review explores the opportunitie...
The study of the role of two-shelled facades in residential buildings in Guilan
In a time when most of the Earth's fossil energy resources are decreasingand the population continue to increase, human needs to control his residentialspace weather in comfort range without any waste or excessive consum...