The role of adipokines and gut hormones in the pathogenesis of obesity, and recent findings for the future treatment of
Journal Title: Scientific Journal of Review - Year 2013, Vol 2, Issue 11
Abstract
Obesity has become one of the leading public health concern.Over one billion people are оverweight or obese and the prevalence of theseconditions is growing constantly. This review presents an overview of theendocrine functions of adipose tissue, the role of gut hormones and theirassociated neuronal networks (the gut-brain axis) in appetite control. Recentstudies have improved our understanding of energy homeostasis by identifyingsophisticated neurohumoral networks that transmit signals between the brain andgut to control food intake. Key adipokines, such as, leptin, adiponectin,interleukin-6, рlasminogen activator inhibitor-1, resistin, tumor necrosisfactor-α, adipsin and acylation stimulating protein, macrophages and monocytechemoattractant protein-1, plasma renin, plasma angiotensin - converting enzymeand angiotensinogen linked with pituitary neuropeptide system began to clarify.Gut hormones, such as, сholecystоkinin, ghrelin, peptide YY, pancreaticpolypeptide, glucagon-like peptide-1, оxyntomodulin, ghrelin, insulin,glucagon, obestatin, amylin аre modulated by acute food ingestion. This articlehighlights some of the recent findings and their implications for the futuretreatment of obesity, but there are currently no effective pharmacologicalinterventions for obesity.
Authors and Affiliations
B. ilkovska| PHO Clinical hospital d-r Trifun Panovski Bitola R.Macedonia., B. Kotevska| Tokuda hospital Sofia R.Bulgaria., D. Labudovic| Department of Medical and Experimental Biochemistry, University School of Medicine, Skopje, Macedonia.
Keywords
Related Articles
- EP ID EP75
- DOI 10.14196/sjr.v2i11.1039
- Views 612
- Downloads 43
Some observations on oestrus manifestations in the red Sokoto goat
This paper reports of some observations on the type and frequency of oestrous expressions in the red sokoto doe (RSD). There is reduced manifestation of oestrous signs in does kept without males. Presence of males and co...
Introduction to calcareous algae in Esfiyukh Mountain
In this research the biostratigraphy in Esfiyukh Mountain (5km of North-east of Torbat-e-Heydarieh) is studied for the first time. Thedeposits in this section are about 175 meters thickness; lithology consists ofalternat...
Comparing the rate of applying knowledge management in guidance schools of education districts 1 and 4 in Tabriz
This study aimed to compare the application of Knowledge Management in Education, Tabriz guidance schools districts 1 and 4 was performed. Research methods, descriptive - survey, and the population is 392 people of pri...
Objective bayesian analysis for the gompertz distribution under doudly type II cesored data
Trimmed samples are widely utilized in several areas ofstatistical practice, especially when some sample values at either or bothextremes might have been adulterated. In this article, the problem ofestimating the paramet...
The applications of wireless sensor networks in military environments
Nowadays, I have to find methods and new weapons on the battlefield to enhance the military capability that the most important is increasing of power in electronic wars. Maybe in the past, many soldiers on the battlefi...