The role of allogeneic hematopoietic stem transplantation in the treatment of solid tumors
Journal Title: Współczesna Onkologia - Year 2006, Vol 10, Issue 1
Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become an established therapeutic approach for many hematological malignancies. Early attempts in transplantation usually used the myeloablative methodology. The myeloablative methodology means complete destruction of recipient bone marrow (including eradication of malignant cells) by the conditioning consisting of megachemotherapy and total body irradiation (TBI). This transplantation strategy has been called classic allo-HSCT. Animal studies performed in the eighties of the 20-th century revealed that myeloablation is not essential for the engraftment, and the conditioning containing immunosuppressive chemotherapy allows the stem cells to create their own marrow space through immunologic reactions, which lead to the reconstitution of hematopoiesis. Thus, non-myeloablative technology has been developed, and now is known as non-myeloablative stem cell transplantation (NST) or transplantation with reduced intensity conditioning (RIC). Clinical benefits and therapeutic successes of NST/RIC in hematological malignancies put certain researchers into the special concern of application of this procedure for the therapy of particular solid tumors. If allo-HSCT plays any role in the treatment of solid tumors, what are the indications for this therapy, and what are the limitations of the procedure, and who will benefit from such treatment. Followed by evidence-based medicine, the authors of the article have provided a comprehensive overview in answering these questions.
Authors and Affiliations
Andrzej Deptała, Alicja Asendrych
Keywords
Related Articles
- EP ID EP83625
- DOI -
- Views 76
- Downloads 0
List do redakcji Współczesnej Onkologii
Primary malignant neoplasms of the tongue
Malignant neoplasms of the tongue are relatively common. Squamous cell carcinoma accounts for approximately 95% of malignant neoplasms in maxillofacial region. Carcinomas of the tongue make up about 40% of all malignant...
Kliniczne znaczenie komplementarnych oznaczeń standardowych markerów nowotworowych i wybranych cytokin w surowicy krwi chorych na raka szyjki macicy
Celem pracy było określenie zależności pomiędzy stężeniami oznaczanych w surowicy krwi markerów nowotworowych (SCC, CEA, CA 125, CYFRY 21.1) i cytokin (IL-6, VEGF) a cechami kliniczno-patologicznymi oraz ocena ich komp...
Wpływ promieniowania jonizującego na DNA komórki
Promieniowanie jonizujące stosowane w radioterapii nowotworów powoduje szereg uszkodzeń materiału genetycznego Może oddziaływać bezpośrednio z cząsteczką DNA wywołując jonizację zasad – jest to tzw efekt bezpośredni lub...
Opinion on fluence of erythropoietin on quality of life and survival in patients with advances non-small cell lung cancer
In the period from 01.2002 to 12.2003 in the Chemotherapy Clinic of the Oncology Centre in Krakow there was conducted a clinical investigation relating the influence of treatment with erythropoietin on advanced non-sma...