The Role of Aripiprazole (An Anti-psychotic Drug) in the Resolution of Acute Peripheral Inflammation in Male Wistar Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 17, Issue 6
Abstract
Aripiprazole, a known second generation anti-psychotic drug has been implicated to possess an anti-inflammatory potential, but yet not scientific adequately explored. This study investigated the role of aripiprazole in the resolution of acute peripheral inflammation in male wistar rats. Thirty six (36) male wistar rats were randomly divided into six groups. Group 1 was given orally 10 ml/kg normal saline while Group 2 received 0.1 ml of 1% carrageenan only at the right hind paw. Group 3 was given orally 0.1 mg/kg aripiprazole while Group 4 animals were administered by oral gavage 0.3 mg/kg aripiprazole. Group 5 was given orally 0.5 mg/kg of aripiprazole while Group 6 received 100 mg/kg aspirin. One hour after administration of either aripiprazole or aspirin, 0.1 ml of 1% carrageenan was injected into the right hind paw of all the groups except Group 1 which received 0.1 ml of normal saline at the right hind paw. There was reduction in paw sizes of the animals given 0.5 mg/kg aripiprazole when compare with the control group (normal saline) at (p<0.05). In conclusion, the study reveals that aripiprazole seems to have anti-inflammatory activities in carrageenan induced paw oedema in male wistar rats.
Authors and Affiliations
L. D. Adedayo, D. A. Olawuyi, A. O. Ojo, O. Bamidele, S. A. Onasanwo, A. O. Ayoka
Keywords
Related Articles
- EP ID EP313025
- DOI 10.9734/JPRI/2017/32601
- Views 99
- Downloads 0
Preliminary Studies on Some Medicinal Plants in Girei, Adamawa State of Nigeria
Ten medicinal plants’ parts (roots, stembarks, and leaves) were studied to assert their suitability for use in pharmaceutical industries as raw materials. The presence (qualitative analysis), concentration (quantitative...
A Retrospective Analysis Regarding Comparative Efficacy and Safety of Hyper-CVAD and MEC Chemo-Protocols in Patients with Chronic Myelogenous Leukemia from Lahore, Pakistan
Background: Chronic myelogenous leukemia (CML) is potentially curable disease of white blood cells (WBCs) especially granulocytes. Our objective was to evaluate comparative efficacy and safety of two chemotherapy protoco...
Evaluation of Oral Examination of Medical Undergraduates in Pharmacology – A Conceptual Study
Aims: Oral examination has held an important place in medicine for centuries. Apart from some advantages, oral examinations are prone to many errors contributing towards threats to validity like Construct Under-represent...
Performance Optimization of Sustained Release Arginine Alginate Microbeads with a Natural Polysaccharide
Objectives: The design of effective and safe novel drug delivery systems has become an integral part for the development and formulating of new medicines. So, research continuously keeps on searching for new ways to deli...
Bioactive Constituents from Apium leptophyllum Fruits
Aims: This study was undertaken to characterize the bioactive constituents of Apium leptophyllum fruits and to evaluate their cytotoxicity, anti-inflammatory and alpha-amylase inhibitory effects. Study Design: Isolation...