THE ROLE OF BETABLOCKERS IN LOWERING THE RISK OF CHEMOTHERAPY-INDUCED HEART FAILURE IN BREAST CANCER
Journal Title: Current Trends in Natural Sciences - Year 2015, Vol 4, Issue 7
Anthracyclines and molecular targeted therapy, pharmacologic agents currently used in breast cancer, are potentially cardiotoxic, leading to cardiac dysfunction, and even to overt heart failure. This paper reviews the art of protecting the heart in breast cancer recipients of chemotherapy with betablockers. The main mechanism of anthracycline induced cardiotoxicity is the oxydative stress, occurring in mitochondrial arena. Recent trials supporting β-blockers cardioprotection in this particular population of patients are discussed. As a result of these studies, betablockers are, along with renin-angiotensin-aldosterone antagonists, statins, and dexrazoxane, the most cardioprotective drugs. The paper also covers some methods (biomarkers, imaging), integrating the sphere of prevention with those of monitoring and treatment. The trials outcomes are illustrated by curves, plots, histograms, tables, etc.
Authors and Affiliations
The screes are the result of interaction between pre-existing rocks and exogenous agents, forming by mechanical disintegration processes, mainly due to cryoclastic (gelivation) processes. Cryoclastic processes are gener...
The species has been an increasing trend in winter wheat crop. Cause is still better adaptability to existing conditions. Variability studies may bring some new information on how this adaptation took place. Racemes fru...
IDENTIFYING ANTHROPOGENIC METALLIC POLLUTANTS USING FREQUENCY DEPENDENT MAGNETIC SUSCEPTIBILITY MEASUREMENTS IN ABUJA METROPOLIS
Soil formed from lithological and weathering processes of parent rocks generally exhibit paramagnetic properties due to some minerals contained in the rocks and thus have significant value of magnetic susceptibility. Th...
The main purpose of the study was to determine the quality of Bratia River. The present paper was based on the bibliographic material as well as the field research carried out during 2016-2017. The research objectives w...
STUDIES ON THE MAJOR FACTORS AFFECTING IN VITRO MICROPROPAGATION OF TWO INTERGENERIC HYBRIDS FRAGARIA × POTENTILLA
In order to establish the major factors affecting in vitro micropropagation of intergeneric hybrids Fragaria × Potentilla, respectively ‘Pink Panda’ and ‘Serenata’, basic culture media Murashige-Skoog (MS), Lee-Fossard...
How To Cite
Adrian Tase (2015). THE ROLE OF BETABLOCKERS IN LOWERING THE RISK OF CHEMOTHERAPY-INDUCED HEART FAILURE IN BREAST CANCER. Current Trends in Natural Sciences, 4(7), -. https://europub.co.uk/articles/-A-25018