The role of Cetuximab in Oral Cavity Cancer: Current views and future prospectives
Journal Title: ΑΡΧΕΙΑ ΕΛΛΗΝΙΚΗΣ ΣΤΟΜΑΤΙΚΗΣ ΚΑΙ ΓΝΑΘΟΠΡΟΣΩΠΙΚΗΣ ΧΕΙΡΟΥΡΓΙΚΗΣ - Year 2016, Vol 17, Issue 2
Abstract
Cetuximab, a monoclonal epidermal growth factor receptor (EGFR) antibody (inhibitor), is one of the most recent treatment options for squamous cell head and neck cancer. The aim of this study is to analyse the current views on its role mainly in the treatment of oral cavity cancer, as well as its future prospectives. We reviewed the most extensive phase III clinical trials on Cetuximab, which played a major role in its approval as a reliable treatment option. A total of six studies were analysed, most of which prove the efficacy of this biological agent on locally advanced, recurrent and metastatic squamous cell head and neck cancer. Cetuximab complements the current treatment protocols and seems to offer an advantage in terms of response, locoregional control of the disease and overall survival.
Authors and Affiliations
Dimitrios MASTAGKAS, Ioannis CHATZISTEFANOU, Charalampos ANDREADIS
Keywords
Related Articles
- EP ID EP267257
- DOI -
- Views 71
- Downloads 0
The evolution of pediatric oral, maxillofacial, and craniofacial surgery, from Hippocrates the Koan to Paul Tessier: a brief historical review.
Pioneers of oral, maxillofacial, and craniofacial surgery moved into uncharted waters when they established oral and cranio-maxillofacial surgery, usually without skilled anesthetists, monitoring devices, surgical intens...
Κροσσωτή χειρουργική κύστη: Αναφορά περίπτωσης μιας σπάνιας οντότητας
ΠΕΡΙΛΗΨΗ: Η κροσσωτή χειρουργική κύστη ή αλλιώς μετεγχειρητική κύστη της άνω γνάθου αποτελεί μια σπάνια βλάβη που παρουσιάζεται κυρίως στην άνω γνάθο σε ασθενείς που έχουν υποβληθεί σε μια χειρουργική επέμβαση στην περιο...
Investigation of etiological factors and evaluation of compliance in patients with craniomandibular disorders
Aim: The aim of this study was to evaluate compliance in treatment of patients with temporomandibular joint disorders and to investigate the association of specific factors with compliance. Material and Methods: The stud...
Lingual nerve impairment following impacted lower 3rd molar removal. A clinical study
Introduction: Lingual nerve injury is one of the most severe post-operative complications that may occur mainly during mandibular third molar surgery. Aim: The aim of this study is to retrospectively examine lingual nerv...
Basal cell adenoma of the parotid. Report of 3 cases
We present 3 cases of basal cell adenoma of the parotid treated at our Department. All patients complained of a retromandibular lump with clinical traits of benign parotid tumors. Diagnostic workup in all cases included...