The role of Cetuximab in Oral Cavity Cancer: Current views and future prospectives
Journal Title: ΑΡΧΕΙΑ ΕΛΛΗΝΙΚΗΣ ΣΤΟΜΑΤΙΚΗΣ ΚΑΙ ΓΝΑΘΟΠΡΟΣΩΠΙΚΗΣ ΧΕΙΡΟΥΡΓΙΚΗΣ - Year 2016, Vol 17, Issue 2
Abstract
Cetuximab, a monoclonal epidermal growth factor receptor (EGFR) antibody (inhibitor), is one of the most recent treatment options for squamous cell head and neck cancer. The aim of this study is to analyse the current views on its role mainly in the treatment of oral cavity cancer, as well as its future prospectives. We reviewed the most extensive phase III clinical trials on Cetuximab, which played a major role in its approval as a reliable treatment option. A total of six studies were analysed, most of which prove the efficacy of this biological agent on locally advanced, recurrent and metastatic squamous cell head and neck cancer. Cetuximab complements the current treatment protocols and seems to offer an advantage in terms of response, locoregional control of the disease and overall survival.
Authors and Affiliations
Dimitrios MASTAGKAS, Ioannis CHATZISTEFANOU, Charalampos ANDREADIS
Keywords
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