THE ROLE OF CSF PCR IN EARLY DIAGNOSIS OF TUBERCULAR MENINGITIS: A STUDY FROM BIDAR DISTRICT
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2014, Vol 1, Issue 6
Abstract
The objective of this study was a study the clinical features and laboratory profile including acid fast bacillus microscopy, cerebrospinal fluid (CSF) culture and M tuberculosis polymerase chain reaction (PCR) for an early diagnosis of tuberculous meningitis. METHODOLOGY: 40 consecutive patients, fulfilling the clinical criteria of tuberculosis meningitis, were included in the study. All patients were subjected to detailed clinical and laboratory evaluation and radiological tests. CSF acid fast bacillus microscopy culture and PCR were carried out in all and results were analyzed. RESULTS: Majority of the patients presented with fever headache, vomiting and signs of meningeal irritation. Ziehl –Neelsen staining for acid fast bacillus was positive in 4% cases, culture in 18% cases and CSF PCR for mycobacterium tuberculosis was positive in 68%. Milliary pattern on chest x-ray was seen in 16% and CNS tuberculomas were seen in 14% cases. CONCLUSION: The CSF PCR estimation in clinically suspected cases of tuberculous meningitis may be an extremely valuable test for early diagnosis and institution of specific therapy.
Authors and Affiliations
Vijay Kumar B. A, Shashank Kulkarni, Yogesh Kamshetty, Shivalingappa Patil, Deepa V. A. , Thirumala Uppar
Keywords
Related Articles
- EP ID EP221396
- DOI 10.18410/jebmh/2014/58
- Views 102
- Downloads 0
TECHNIQUES AND EARLY RESULTS OF MINI LEFT THORACOTOMY APPROACH FOR REPAIR OF TETRALOGY OF FALLOT
BACKGROUND Right minithoracotomy and lower partial sternotomy are usual approaches for mini-invasive repair of congenital cardiac defects with a better cosmetic outcome. These approaches have been inadequate for repair o...
A STUDY ON THE LIPID PROFILE OF HYPERTENSIVE PATIENTS IN UTTARA KANNADA DISTRICT
BACKGROUND Abnormalities of lipid and hypertension usually coexist. Epidemiological studies have demonstrated that cholesterol levels are significantly higher in hypertensive patients with demographically matched normote...
A CASE OF HASHIMOTO’S THYROIDITIS WITH AUTOIMMUNE HAEMOLYTIC ANAEMIA
Hashimoto’s thyroiditis is a part of the spectrum of autoimmune thyroid disease and it is found to be associated with other autoimmune diseases like Addison’s disease, vitiligo, type1 diabetes mellitus, alopecia areata,...
A STUDY OF CARDIAC DISEASES IN PATIENTS WITH CHRONIC KIDNEY DISEASE
BACKGROUND The heart and the kidneys are tightly interlinked with each other. So, primary disorder of one of these organs often results in the secondary dysfunction of other. The patients with CKD most of the times die f...
HAPTIC LOCATION IN PSEUDOPHAKIC EYES AND NONINFECTIOUS POSTOPERATIVE INFLAMMATION- A PROSPECTIVE STUDY
BACKGROUND Postoperative noninfectious inflammation after cataract surgery, which can be persistent, remains an undesirable consequence despite many advances in surgical techniques. This ocular inflammation after catarac...