The Role of CT Perfusion Parameters in Grading of Brain Gliomas in Correlation with Histopathology
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Glioma is a primary brain tumor that arises from the supportive cells of the brain. Grading of gliomas is essential in planning therapeutic approach, assess response to therapy and to prognosticate the tumor. The aim of this study was to find the most sensitive and specific CT perfusion parameters and their cut offs that can be used to differentiate low and high grade brain gliomas and to compare CT perfusion parameters with histopathological grading of the glioma. Methods and Materials: We performed CT perfusion (CTP) in 50 patients, with age ranging from 20 to 70 years, having brain glioma diagnosed by conventional and contrast enhanced MRI and Time-attenuation curves were obtained and quantitative perfusion parameters were calculated by applying neuro perfusion software which include Cerebral Blood Volume (CBV), Cerebral Blood Flow (CBF) and Permeability Surface area product (PMB). Results: Comparing the CT perfusion parameters between high grade and low grade gliomas showed that there is a highly significant increase of CBF, CBV and PMB among high grade tumor group versus low grade group. Conclusion: Significant differences in perfusion parameters between low and high grade gliomas were apparent in this study. CT perfusion may be of great clinical use in differentiation between low and high grade gliomas. In our study we found that the tumor blood flow (CBF) and tumor permeability (PMB) are the most sensitive CT perfusion parameters rather than tumor blood volume (CBV) in glioma grading.
Authors and Affiliations
Satheesh Kumar E, D. Ramesh, N. Kailasanathan
Keywords
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