The Role of Damage-Associated Molecular Patterns in Human Diseases Part I - Promoting inflammation and immunity
Journal Title: Sultan Qaboos University Medical Journal - Year 2014, Vol 15, Issue 1
Abstract
Tere is increasing interest by physicians in the impact of the innate immune system on human diseases. In particular, the role of the molecules that initiate and amplify innate immune pathways, namely damage-associated molecular patterns (DAMPs), is of interest as these molecules are involved in the pathogenesis of many human disorders. Te frst part of this review identifes fve classes of cell stress/tissue injury-induced DAMPs that are sensed by various recognition receptor-bearing cells of the innate immune system, thereby mounting inflammation, promoting apoptosis and shaping adaptive immune responses. Te DAMPs activate and orchestrate several innate immune machineries, including inflammasomes and the unfolded protein response that synergistically operates to induce inflammatory, metabolic and adaptive immune pathologies. Two examples of autoimmune diseases are discussed as they represent a typical paradigm of the intimate interplay between innate and adaptive immune responses.
Authors and Affiliations
Walter G. Land| Laboratoire d’ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx Transplantex, Centre de Recherche d’Immunologie et d’Hématologie, Université de Strasbourg, Strasbourg, France
Keywords
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