The role of different monocyte subsets and macrophages in asthma pathogenesis
Journal Title: Progress in Health Sciences - Year 2015, Vol 5, Issue 1
Abstract
Monocytes are comprised of three phenotypically and functionally distinct subsets: classical CD14++CD16-, intermediate CD14++CD16+ and non-classical CD14+CD16++ cells that can play differential roles in regulation of both systemic and local inflammatory processes. In addition, these monocyte subsets represent differential developmental stages with CD16-positive monocytes being the most mature cells that can be considered direct precursors of tissue macrophages. Monocytes and, most significantly, monocyte-derived macrophages constitute an important component of both normal and asthmatic airways. Here we summarize the current knowledge on the roles of monocytes and macrophages in asthma pathogenesis. In addition, we discuss here the usefulness of standard and potential monocyte-directed anti-asthmatic therapeutic approaches.
Authors and Affiliations
K. Grubczak, M. Moniuszko
Keywords
Related Articles
- EP ID EP76681
- DOI -
- Views 95
- Downloads 0
Progressive paraparesis in 14 - year-old male with kyphoscoliosis: A case report
A 14-year-old male presented with congenital kyphoscoliosis along with progressive paraparesis. Radiographs confirmed kyphoscoliosis and magnetic resonance imaging revealed a stretched and flattened spinal cord over the...
Female genital mutilation in light of Polish criminal law
Introduction: Female genital mutilation is a practice that causes devastating physical, psychological, and social consequences for girls and women. Female genital mutilation is internationally recognized as a violation...
Electrophoretical mobility of nuclei in buccal cells of cystic fibrosis patients
Introduction: Cystic fibrosis (CF) is inherited, metabolic, multisystem disease with various clinical symptoms. In the airways neutrophilic inflammation and increased levels of neutrophil elastase (NE) are observed even...
Mobile-phone addiction in adolescence: The Test of Mobile Phone Dependence (TMD)
Introduction: The mobile phone is among the technological tools with the greatest presence in the market. During a period of scarcely 10 years, it has gone from being almost non-existent to being the device most used (an...
Advance care planning in Spain. A short national report. Part I
Purpose: Ethical and legal recognition of patient autonomy and rights is a reality in Spain. Together with informed consent, advance directives and advance care planning have also played a major role in bringing about th...