The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies
Journal Title: Journal of Clinical Hepatology - Year 2024, Vol 40, Issue 11
Abstract
Non-alcoholic fatty liver disease （NAFLD） is a series of diseases characterized by hepatic steatosis and is also a metabolism-associated disease and an important factor for liver fibrosis， liver cirrhosis， and hepatocellular carcinoma. Endoplasmic reticulum is a core organelle for the regulation of lipid metabolism， and unfolded protein response is an important process of endoplasmic reticulum stress （ERS）. Based on the important stress role of endoplasmic reticulum in metabolism-associated diseases， this article explores the influencing mechanism between ERS and NAFLD and reviews the research advances in lipid metabolism， inflammatory response， hepatocyte death， fibrosis， and ERS-targeted therapies in the pathological development of NAFLD.
Authors and Affiliations
Xiuyan LI, Na LEI, Hongfei SONG, Ling ZENG, Dong WANG, Jie MU
Keywords
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- EP ID EP753487
- DOI 10.12449/JCH241126
- Views 7
- Downloads 1
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Non-alcoholic fatty liver disease （NAFLD） is a series of diseases characterized by hepatic steatosis and is also a metabolism-associated disease and an important factor for liver fibrosis， liver cirrhosis， and hepato...