The role of endothelin in stroke: Experimental data and underlying pathophysiology
Journal Title: Archives of Medical Science - Year 2006, Vol 2, Issue 3
Abstract
The role of endothelin in functional and structural changes after stroke is only partly understood: synthesis and release of the potent vasoconstrictor peptide endothelin-1 increases following ischemia and mediates the delayed hypoperfusion associated with ischemia, but the role of the other two endothelin subtypes remains unclear. Only little is known about its mode of action in ischemia. Recently developed selective peptide and non-peptide antagonists and agonists acting at the level of endothelin receptors provide useful tools for further investigation of the physiological role of endothelin and its impact on pathophysiological processes in different neurological diseases including ischemic, nonhemorrhagic stroke and cerebral vasospasm. The present review supports experimental and clinical evidence that vasoactive mediators, and endothelin-1 in particular, are important contributors to the pathogenesis of cerebral ischemic damage in animal models and in humans. Special reference is given to explain the few clinical data in the light of experimental results.
Authors and Affiliations
Bernhardt Schaller
Neopterin and circulating adhesion molecules as prognostic markers in childhood asthma
Introduction: The purpose of this study was to determine the serum levels of neopterin and circulating adhesion molecules sICAM-1, sE-selectin and sL-selectin in children with stable asthma in order to investigate thei...
Thoracoscopic splanchnicectomy in chronic epigastric visceral pain therapy
Background: The rapid development of minimal invasive surgery in the 1990s coincided with the introduction of videothoracoscopic splanchnicectomy of nerve fibers engaged in the sensation of chronic pain related with adva...
Reference curves of anthropometric indices and serum lipid profiles in representative samples of Asian and European children
Short-term lifestyle intervention significantly increases fasting adiponectin and induces a decline in serum adiponectin during oral glucose tolerance test, without changes in insulin resistance
Introduction: Metabolic syndrome is associated with insulin resistance (IR) and low concentrations of adiponectin, an adipocytokine that improves insulin sensitivity and has anti-inflammatory and anti-atherogenic propert...
Medical Education and the Bologna Process