The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabetes An In Silico Study
Journal Title: International Journal of Trend in Scientific Research and Development - Year 2021, Vol 5, Issue 5
Abstract
Diabetes is one of the major causes of death in the world, affecting around 422 million people or 8.5 percent of the worlds population . Diabetes mellitus, or diabetes, is a disease that causes excessive blood sugar levels. Diabetes mellitus is a condition where a person does not produce enough insulin or does not link directly to insulin, and resulting in excessively high blood sugar glucose levels. Diabetes is classified into several types Prediabetes, Type 1 diabetes, Type 2 diabetes and gestational diabetes. In diabetes research, numerous bioinformatics technologies are used. The current research was carried to study the effect of naturally occurring compounds against Aquaporin 2 as the target protein molecule with the help of molecular docking for diabetes diagnosis. AQP2 is found in the apical cell of the main ducts of the kidney and in the vesicles intracellular in the cells. Docking experiment were performed out by using aquaporin 2 4nef . The technique of molecular docking was utilized to investigate the potential of naturally occurring compounds such as aglycone, gedunin, and harman with the target protein Aquaporin 2 4nef . In diabetes, gedunin may function as a therapeutic drug against the disease causing protein Aquaporin 2 4nef . Further research and then certain clinical and pre clinical studies may be allowed to discover drugs that can be used to treat diabetes. Ayushi Chaudhary | Noopur Khare | Tripti Bhatnagar | Abhimanyu Kumar Jha "The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabetes: An In Silico Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43788.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43788/the-role-of-gedunin-against-aquaporin-2-for-the-possible-treatment-of-diabetes-an-in-silico-study/ayushi-chaudhary
Authors and Affiliations
Ayushi Chaudhary | Noopur Khare | Tripti Bhatnagar | Abhimanyu Kumar Jha
Keywords
Related Articles
- EP ID EP699582
- DOI -
- Views 49
- Downloads 0
Poultry Vaccines and Vaccination Practices among Farmers in Wukari, Taraba State Nigeria
Poultry enterprise is increasingly gaining viability owning to successful preventive measures of vaccination protocols for various diseases of economic importance. A cross sectional study involving forty five 45 poultry...
Importance of Solar Energy in Day to Day Life
The natural world has used the sun’s energy since the beginning of time, and while there has been lots of discussion about this, the truth is that the sun is both a problem and a solution. Solar energy is an unchanging...
Image Processing Application for Vehicle Seat Vacancy Identification
The importance of embedded applications on image and video processing domain has been taking a larger space. The image processing is the study of several algorithms that takes an image as input and returns an image as ou...
Basic Features and Strategies of Women’s Empowerment of a Developing Urban Area – A Case Study of Memari Municipality, Purba Bardhaman, West Bengal, India
Women’s Empowerment is a holistic and sustainable goal for development of a society. They are the resources of family, society, community and nation. They are the greatest asset of an economy. Urbanization processes are...
Acoustic-The Way of Utilizing the Resource for Research and Technology Implementation to Domestic Equipments, An Introductory Overview
Acoustics is the study of small pressure waves or sound waves in air which can be detected by the human beings. The scope of acoustics is not limited and extended to lower and higher frequencies: ultrasound and infrasoun...