The role of glutamine and α-ketoglutarate in gut metabolism and the potential application in medicine and nutrition
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
An amino acid, Glutamine (Gln), is abundant in both the human body and diet. Gln and its derivatives are important factors affecting intestinal function, growth and development as a main source for energy and structure component. The importance to metabolism is evident during stress. During the past 2 decades, an increased understanding has been gained into its role in metabolism. Gln is currently classified as a conditionally essential amino acid; however, it is unstable in water solution and produces toxic byproducts on decomposition, which has led to the commercialization of its precursor - AKG. Apart from its nutritive role, Gln and AKG possess certain pharmacologic and/or immunologic effects. The article presents the role of Gln and AKG in gut metabolism and, on the basis of clinical trials and animal experiments, discusses their potential usefulness in medicine and nutrition.
Authors and Affiliations
Rafał Filip, Stefan G. Pierzynowski
Keywords
Related Articles
- EP ID EP58558
- DOI -
- Views 93
- Downloads 0
Application of silymarin in human and animal medicine
Silymarin, the polyphenolic fraction from Milk Thistle ([i]Silybum marianum[/i]) and its main component silybinin, are used almost exclusively for hepatoprotection in humans. Silymarin offers good protection in various t...
Trace elements as constituents of antioxidative proteins
The human body is under constant attack by free radicals (reactive oxygen species – ROS). Free radicals are highly reactive molecules generated by biochemical redox reactions which occur as a part of regular cell metabo...
Euthanasia – the right to die? Part I: Race hygiene and eugenics in Germany and the United States 1859-1914
The article (Part I of 3)* outlines the advent and development of social Darwinism from the mid-1880s until the outbreak of World War I. Based on Darwin’s theory of evolution and the ‘survival of the fittest’ in the plan...
Epidemiological analysis of 22 patients with congenital bleeding diathesis hospitalized in the Department of Maxillofacial Surgery in Lublin, Poland, 2008–2013
[b]Introduction. [/b]Haemophilia A and B are congenital bleeding disorders caused by coagulation factor VIII or IX deficiency. Haemophilia A and B occur in men, like all qualities dependent on genes linked to gender, whe...
Application of high performance thin layer chromatography method for ophthalmological preparations containing anthocyanins fractions
The aim of the investigation was to elaborate a fast, easy, and cheap method of analysis of ophthalmological preparations containing anthocyanins fractions. A high performance thin layer chromatography (HPTLC) was applie...