The Role of Heat Shock Proteins in Alzheimer Disease: A Systematic Review

Journal Title: Journal of Syndromes - Year 2016, Vol 3, Issue 1

Abstract

Background: Recent studies have shown that heat shock proteins (HSPs) play a role in pathogenesis of Alzheimer’s disease. Objectives: In this review article we investigated the role of HSPs in pathogenesis of cognitive disorders such as Alzheimer’s disease. Data sources: We have reviewed publications from the electronic databases of Medline/PubMed, Scopus, Google Scholar, Embase, ISI Web of Knowledge, Biological Abstracts and Chemical Abstracts with keywords of Heat Shock Protein (HSP), Neurocognitive disorders, Alzheimer’s disease and Dementia. Study eligibility criteria: After search of data basis with above keywords we found 337 papers published. Then we narrowed our findings to 40 articles and reviewed them. Results: Results of our study showed that heat shock proteins (HSPs) help refold or degrade mis-folded proteins, reduce abnormal protein accumulation and dysfunction of synapses, neuronal degeneration and gradual and continuous loss of cognitive function in Alzheimer’s disease and improves the associated symptoms.

Authors and Affiliations

Mohammad Kiani

Keywords

Related Articles

Ehlers-Danlos Syndrome or Disease?

Although first described in 1892 by Tschernogobow in Moscow, the medical history of Ehlers-Danlos syndrome (EDS) begins with Edward Ehlers’s description in 1900 in Copenhagen. Several avatars would come to stymie its ide...

Recurrence of Ogilvie’s Syndrome, a Rare Postoperative Complication in Second Caesarean Section

Acute colonic pseudo obstruction (ACPO), also known as Ogilvie’s syndrome is a very rare postoperative complication of Caesarean section. It has classically been reported in critically ill patients and following cardiac...

Blood Zinc Levels and OxidativeStress Parameters in Children and Adolescents with Down Syndrome

Down Syndrome (DS), or trisomy 21, occurs in one out of 700-1000 live births. It is commonly observed that DS patients present obesity and zinc deficiency. Zinc deficiency could be related to overactivity of the enzyme C...

The Role of Heat Shock Proteins in Alzheimer Disease: A Systematic Review

Background: Recent studies have shown that heat shock proteins (HSPs) play a role in pathogenesis of Alzheimer’s disease. Objectives: In this review article we investigated the role of HSPs in pathogenesis of cognitive...

IPEX Syndrome, FOXP3 and Cancer

In this review, we introduce the IPEX syndrome and its relationship with germline mutations of the FOXP3 gene. We then describe the multiple functional roles of FOXP3 in regulatory T cells and epithelial cells as well as...

Download PDF file
  • EP ID EP206059
  • DOI 10.13188/2380-6036.1000008
  • Views 108
  • Downloads 0

How To Cite

Mohammad Kiani (2016). The Role of Heat Shock Proteins in Alzheimer Disease: A Systematic Review. Journal of Syndromes, 3(1), 1-6. https://europub.co.uk/articles/-A-206059