The Role of Heat Shock Proteins in Alzheimer Disease: A Systematic Review
Journal Title: Journal of Syndromes - Year 2016, Vol 3, Issue 1
Abstract
Background: Recent studies have shown that heat shock proteins (HSPs) play a role in pathogenesis of Alzheimer’s disease. Objectives: In this review article we investigated the role of HSPs in pathogenesis of cognitive disorders such as Alzheimer’s disease. Data sources: We have reviewed publications from the electronic databases of Medline/PubMed, Scopus, Google Scholar, Embase, ISI Web of Knowledge, Biological Abstracts and Chemical Abstracts with keywords of Heat Shock Protein (HSP), Neurocognitive disorders, Alzheimer’s disease and Dementia. Study eligibility criteria: After search of data basis with above keywords we found 337 papers published. Then we narrowed our findings to 40 articles and reviewed them. Results: Results of our study showed that heat shock proteins (HSPs) help refold or degrade mis-folded proteins, reduce abnormal protein accumulation and dysfunction of synapses, neuronal degeneration and gradual and continuous loss of cognitive function in Alzheimer’s disease and improves the associated symptoms.
Authors and Affiliations
Mohammad Kiani
Keywords
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- EP ID EP206059
- DOI 10.13188/2380-6036.1000008
- Views 127
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