The Role of Heat Shock Proteins in Alzheimer Disease: A Systematic Review

Journal Title: Journal of Syndromes - Year 2016, Vol 3, Issue 1

Abstract

Background: Recent studies have shown that heat shock proteins (HSPs) play a role in pathogenesis of Alzheimer’s disease. Objectives: In this review article we investigated the role of HSPs in pathogenesis of cognitive disorders such as Alzheimer’s disease. Data sources: We have reviewed publications from the electronic databases of Medline/PubMed, Scopus, Google Scholar, Embase, ISI Web of Knowledge, Biological Abstracts and Chemical Abstracts with keywords of Heat Shock Protein (HSP), Neurocognitive disorders, Alzheimer’s disease and Dementia. Study eligibility criteria: After search of data basis with above keywords we found 337 papers published. Then we narrowed our findings to 40 articles and reviewed them. Results: Results of our study showed that heat shock proteins (HSPs) help refold or degrade mis-folded proteins, reduce abnormal protein accumulation and dysfunction of synapses, neuronal degeneration and gradual and continuous loss of cognitive function in Alzheimer’s disease and improves the associated symptoms.

Authors and Affiliations

Mohammad Kiani

Keywords

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The Role of Heat Shock Proteins in Alzheimer Disease: A Systematic Review

Background: Recent studies have shown that heat shock proteins (HSPs) play a role in pathogenesis of Alzheimer’s disease. Objectives: In this review article we investigated the role of HSPs in pathogenesis of cognitive...

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  • EP ID EP206059
  • DOI 10.13188/2380-6036.1000008
  • Views 107
  • Downloads 0

How To Cite

Mohammad Kiani (2016). The Role of Heat Shock Proteins in Alzheimer Disease: A Systematic Review. Journal of Syndromes, 3(1), 1-6. https://europub.co.uk/articles/-A-206059