The Role of Herpes Family Viruses in the Pathogenesis of Paranoid Schizophrenia: the Data of Multidimensional Correlations of Immunological, Morphological and Clinical Characteristics
Journal Title: International Neuropsychiatric Disease Journal - Year 2015, Vol 3, Issue 3
Abstract
The majority of current researches of participation of herpes viruses in pathogenesis of schizophrenia are aimed at detection of increased specific antibodies level. Works studying polymodal system connections between antibodies to herpes viruses, other immunity parameters, structural brain changes and psychopathology symptoms in schizophrenia do not occur practically. The aim was to investigate the systemic relationships present between parameters of the immune system, including the level of serum antibodies to herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), cytomegalovirus (CMV), and Epstein-Barr virus (EBV), structural anomalies of brain and clinical symptoms of schizophrenia. Material and Methods: The study included data of investigation of 30 patients with episodic paranoid schizophrenia with progressing and stable defect and positive symptoms in remissions (EPSPSD) (main group) and 32 patients with episodic remittent paranoid schizophrenia (ERPS) (controls). We determined the leukocyte content, the lymphocyte subpopulations and the leukocyte phagocytosis in PHAGOTEST with fluorescein (FITC)-labeled opsonized bacteria and calculated the phagocytic index (PhI), the circulating immune complexes (CIC) level by spectrophotometry. The antibodies against herpes viruses were determined using the ELISA test. Total serum immunoglobulins, IgG, IgM, and IgA were determined by immunoturbidimetry. Clinical psychiatric examination, BPRS and MRI examination were used. Results: MRI-signs of brain structures abnormalities, including hemodynamic disorders and developmental brain anomalies, were identified. Levels of IgG to studied herpes viruses were increased, levels of IgM to all studied herpes viruses differed from 0. The interactions of morphological, clinical and immunological parameters were defined. Conclusion: These results demonstrate a definite link between herpes infection and the immune, clinical and morphological parameters of patients with the episodic paranoid schizophrenia with progressing and stable defect. The results confirm the infectious theory of the diseases.
Authors and Affiliations
Irina I. Mikhailova, Vera A. Orlova, Vitaly L. Minutko, Tatjana P. Berezovskaya
Keywords
Related Articles
- EP ID EP241531
- DOI 10.9734/INDJ/2015/14462
- Views 121
- Downloads 0
The Effectiveness of Substance Abuse Management: Perspectives of Nurses in Neuropsychiatric Hospital, Aro, Abeokuta, Ogun State, Nigeria
The study assessed the perspectives of nurses in Neuropsychiatric Hospital, Aro, Abeokuta, Nigeria on the effectiveness of substance abuse management. It made use of a descriptive research design. The study was conducted...
Adolescent Students’ Knowledge of Depression and Appropriate Help-seeking in Nigeria
Aim: Globally, but even more remarkably in developing countries, many young people suffer from untreated depression despite the availability of evidence-based treatment. Utilisation of mental health resources is hinged o...
The Lived Experiences of Persons with Mental Health Disorders in Public Sector Employment in the Niger Delta Region of Nigeria
Aims: Relative to studies of lived experiences of people with mental health disorders in developed countries, no research has focused on the lived experiences of persons living with mental health disorders in the Niger D...
Training Contributions of Executive Functions in Perception of Quality of Life in Elderly
Aims: Verify the presence or lack of improvement in quality of life perception, comparing the results of the evaluation from both elderly groups that participated on the executive functions training research. Study Desig...
Substance Use Disorder: Biological Mechanisms, Clinical Effects and Neuroadaptations
Substance use disorder is characterized by a psychological dependence on a substance or a drug that is beyond voluntary control and that can cause serious harm to the individual when used repetitively. The use of drugs,...