The Role of Indirect Immunofluorescence Methods in the Detection of Autoimmune Antibodies in Thyroid Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 24, Issue 3
Abstract
Aims: In this study, we evaluated the prevalence of antithyroglobulin antibodies (anti-Tg Ab) and antipyroxidase antibodies (anti-TPO Ab) in thyroid disease and investigated the role of indirect immunofluorescence methods in its detection. Study Design: The study was carried out on 87 patients with thyroid disorders. Place and Duration of Study: The patients were recruited from the Department of Internal Medicine and the Department of Surgery at Aleppo University Hospital. A group of 25 matched volunteers were included as a control group for the investigation. Data analyzed in this study was collected over the period from December 2005 to February 2006. Methodology: Immunofluorescence methods were used to study the prevalence of antithyroglobulin antibodies (anti Tg Ab) and anti pyroxidase antibodies (anti TPO Ab) in patients with different thyroid diseases. Results: We found that anti-Tg Ab was positive in 33% of patients with goiters, 40% of patients with hyperthyroidism, 73% of patients with Hashimoto's thyroiditis, and 25% of patients with nodules. Anti-Tg Ab was positive in only 4% of the control group. Similarly, anti-TPO Ab was positive in 37% of patients with goiters, 73% of patients with hyperthyroidism, 88% of patients with Hashimoto's thyroiditis, and 50% of patients with nodules. Anti-TPO Ab was found positive in 8% of the control group. Conclusion: Taken together, these results suggest anti-Tg Ab and anti-TPO Ab measurements are an important step in the evaluation and management of thyroid disorders. Anti-TPO Ab had the highest sensitivity in predicting thyroidal disorders. Immunofluorescence techniques, furthermore, were found to be a reliable method for the evaluation of these disorders.
Authors and Affiliations
Nourdin Kadi, Lina Kayali
Keywords
Related Articles
- EP ID EP312539
- DOI 10.9734/JAMMR/2017/36949
- Views 61
- Downloads 0
Role of Different Ovulation Induction Protocols in Follicular Growth, Estradiol and Pregnancy Rates for Women with Unexplained Infertility and Polycystic Ovary Syndrome Undergoing Intrauterine Insemination
Introduction: The study aimed to study the effects of ovulation induction programs on the number of pre-ovulatory dominant follicles and endometrial thickness, their effects on pre-ovulatory estradiol 2 levels, and to de...
OCT- An Emerging Diagnostic Tool in Sensing Marginal Integrity of Nano Composites
Objectives: The purpose of the present research was to demonstrate images of failure into the structure of nano composites using optical coherence tomography. Methods: Ten human third mandibular molars were taken in the...
Association of Ischemic Contracture, Hypercontracture and Post-Ischemic Recovery in Diabetic Rat Heart
Objective: Previous studies suggest a relation among ischemic contracture and/or hypercontracture profiles and the functional responses in diseased hearts isolated from hypothyroid and post-infarcted animals. We therefor...
Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Acute Myocardial Infarction Due to Myocardial Bridging: A Clinical Dilemma
A 51-year-old male with a family history of premature coronary artery disease (CAD) presented with acute myocardial infarction (AMI) with coronary angiography demonstrating no angiographic disease and a mid-left anterio...
Functional Assessment in Greek Tension-Type Headache Sufferers: Validity, Reliability, Responsiveness and Psychometrics of the Migraine Disability Assessment Questionnaire (MIDAS)
Introduction: Functional assessment in painful musculoskeletal disorders such as tension-type headache requires valid, reliable and sensitive instruments. MIDAS (Migraine Disability Assessment questionnaire) is an intern...