The Role of Indirect Immunofluorescence Methods in the Detection of Autoimmune Antibodies in Thyroid Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 24, Issue 3
Abstract
Aims: In this study, we evaluated the prevalence of antithyroglobulin antibodies (anti-Tg Ab) and antipyroxidase antibodies (anti-TPO Ab) in thyroid disease and investigated the role of indirect immunofluorescence methods in its detection. Study Design: The study was carried out on 87 patients with thyroid disorders. Place and Duration of Study: The patients were recruited from the Department of Internal Medicine and the Department of Surgery at Aleppo University Hospital. A group of 25 matched volunteers were included as a control group for the investigation. Data analyzed in this study was collected over the period from December 2005 to February 2006. Methodology: Immunofluorescence methods were used to study the prevalence of antithyroglobulin antibodies (anti Tg Ab) and anti pyroxidase antibodies (anti TPO Ab) in patients with different thyroid diseases. Results: We found that anti-Tg Ab was positive in 33% of patients with goiters, 40% of patients with hyperthyroidism, 73% of patients with Hashimoto's thyroiditis, and 25% of patients with nodules. Anti-Tg Ab was positive in only 4% of the control group. Similarly, anti-TPO Ab was positive in 37% of patients with goiters, 73% of patients with hyperthyroidism, 88% of patients with Hashimoto's thyroiditis, and 50% of patients with nodules. Anti-TPO Ab was found positive in 8% of the control group. Conclusion: Taken together, these results suggest anti-Tg Ab and anti-TPO Ab measurements are an important step in the evaluation and management of thyroid disorders. Anti-TPO Ab had the highest sensitivity in predicting thyroidal disorders. Immunofluorescence techniques, furthermore, were found to be a reliable method for the evaluation of these disorders.
Authors and Affiliations
Nourdin Kadi, Lina Kayali
Keywords
Related Articles
- EP ID EP312539
- DOI 10.9734/JAMMR/2017/36949
- Views 83
- Downloads 0
Effects of Three Different Modes of Exercise Training on Plasma Lipoprotein Profile in Healthy Men
Objective: The present study was designed to compare the effects of resistance, endurance, and combined endurance / resistance exercises on plasma lipid and lipoprotein profile in healthy untrained middle-aged men. Metho...
The Effect of Body Mass Index and Waist Circumference on Blood Pressure
This study was aimed at determining the pattern of some assessors of obesity including body mass index (BMI) and waist circumference (WC) and the effect of these parameters on blood pressures in the studied population. T...
The Incidence of Hypersplenism in Decompensated Liver Cirrhosis of Alcoholic Etiology
Introduction: Liver cirrhosis is a terminal, morpho-functional entity of hepatic dysfunction, which is characterized by the replacement of the hepatic lobule connective tissue nodules. Splenomegaly is a common finding in...
Comparison of Various Phenotypic Methods for the Detection of Metallo-beta-lactamases in Pseudomonas aeruginosa
Aims: To evaluate the screening antibiotic and phenotypic test that can be used to confirm metallo-beta-lactamase (MBL) production in clinical isolates of Pseudomonas aeruginosa and to find out the prevalent MBL gene in...
A Case of Pediatric Pertussis Unhesitatingly Diagnosed with the Insight of Microbiology Laboratory
We describe a pediatric pertussis case occurred in an unvaccinated six-month-old male infant. The newborn patient was rapidly diagnosed by means of the insight of the clinical microbiology laboratory, despite the absen...