The role of intestinal microbiome in the progression of non-alcoholic fatty liver disease
Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 4
Abstract
Non-alcoholic fatty liver disease (NAFLD) is considered an important and economically significant public health problem, its progression can result in development of cirrhosis and hepatocellular carcinoma. Over the past two decades, NAFLD became the most widespread liver disease worldwide, affecting 25 % of the adult population globally with a range of 13.5 % in Africa, 30.4 % in South America and 31.8 % in the Middle East. NAFLD is a multifactorial disease, its onset results from the interaction of genetic predisposition and metabolic, inflammatory and environmental factors. The intestinal microbiome dysregulation, directly associated with the NAFLD development, plays the main role. The quantitative and qualitive microbiome composition may be affected by nutrition that results in dysbiosis, a diet rich in saturated fats, animal products and fructose. The species diversity of intestinal bacteria affects the absorption of both macro- and micronutrients, initiating many pathways that contribute to the accumulation of fat in the liver and trigger inflammatory cascades that provoke liver damage. The mechanisms of NAFLD development, associated with intestinal dysbiosis, include bacterial overgrowth syndrome, synthesis of endogenous ethanol and the development of endotoxinemia. In addition, they include dysregulation of short-chain fatty acids and branched-chain amino acids. Excess or lack of nutrients from food, in particular, of fructose and choline, also associated with the development of non-alcoholic fatty liver disease through gut microbiota. Debatable is a question about effects of intestinal dysbiosis on the progression of non-alcoholic fatty liver disease. The review presents discussion of the relationship between gut microbiota and other risk factors for the NAFLD progression, as well as the analysis of the role of intestinal dysbiosis in its pathogenesis.
Authors and Affiliations
G. D. Fadieienko, O. Y. Gridnyev, N. I. Chereliuk, O. G. Kurinna
Keywords
Related Articles
- EP ID EP670166
- DOI 10.30978/MG-2019-4-92
- Views 119
- Downloads 0
Vegetative accompaniment of the combined course of gastroesophageal reflux disease in young patients with autoimmune thyroiditis
Objective — to establish the presence of autonomic dysfunction and to assess the frequency and severity of its manifestations in patients with autoimmune thyroiditis (AIT) and gastroesophageal reflux disease (GERD) with...
The interrelation between disorders of intestinal microbiocenosis and level of serum serotonin in patients with diabetic enteropathy
Objective — to investigate the interrelation between disorders of intestinal microbiocenosis and the level of serum serotonin in patients with type 2diabetes mellitus (DM 2). Materials and methods. The investigation has...
Pathogenetic role of visceral adipose tissue in the development of non-alcoholic fatty liver disease in patients with metabolic syndrome
Objective — to study the nature of changes in carbohydrate and lipid metabolism, depending on the distribution and activity of visceral adipose tissue (VAT), and the degree of liver steatosis in patients with nonalcoholi...
Sate of intestinal microbiome in patients with osteoarthritis
Objective — to study the composition of intestinal microflora (CM) in patients with osteoarthritis (OA) against the background of administration of non-steroidal anti-inflammatory drugs (NSAIDs) and without them, as well...
Clinical case of the Wasserman false positive test at the autoimmune hepatitis combined with antiphospholipid syndrome
The article briefly describes treponemal and non-treponemal serological tests that are used to diagnose syphilis, as well as the causes of false positive results of these tests. A clinical observation has been presented...