The Role of Ki-67 In Predicting Prognosis And Overall Survival In Pediatric Gastrointestinal Lymphoma
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Background: The variable prognosis of gastrointestinal lymphoma within a pathological stage necessitates the identification of subgroups of patients with a more aggressive disease. Aims and Objectives: The aim of the present study was to identify the incidence and distribution of paediatric lymphomas, to assess conventional morphological prognostic parameters among the various histopathological subtypes by immunophenotyping and to evaluate the expression of Ki67 in GI lymphoma and correlate with several clinico-pathological features and prognosis. Materials and methods: Formalin-fixed paraffin-embedded tissue samples from 30 paediatric cases treated by surgical resection for gastrointestinal lymphoma in the year 2008 to 2014 were studied by immunohistochemistry, using monoclonal antibodies to Ki67,CD3,CD20 and CD45. Results: The results were correlated with clinico-pathological features. Higher Ki-67 labeling index correlated significantly with overall survival rate. The mean Ki-67 labeling index was higher in aggressive lymphoma such as Burkitt, Anaplastic lymphoma and Diffuse large B cell lymphoma. Ki-67 was identified as important prognostic factors. Conclusion: In this study, 60% Ki 67 cut-off value appear to have a predict value for overall survival and help clinicians to distinguish between GI lymphoma with good and poor outcome. Follow up of these patients for 10 more years could throw more light on the role of Ki-67 LI as long term prognostic indicators.
Authors and Affiliations
Dr. S. Selvi, Dr. M. Satish Devakumar, Dr. T. Chitra
Keywords
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- EP ID EP588070
- DOI 10.9790/0853-1601012836
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