THE ROLE OF MAIT CELL IN PROTECTION AGAINST INFECTION IN-VIVO
Journal Title: International Journal of Medical and Biomedical Studies - Year 2018, Vol 2, Issue 6
Abstract
MAIT cells are also activated during human viral infections, yet it remains unknown whether MAIT cells play a significant protective or even detrimental role during viral infections in vivo. Using murine experimental challenge with two strains of influenza A virus, we show that MAIT cells accumulated and were activated early in infection, with upregulation of CD25, CD69 and Granzyme B, peaking at 5 days post infection. Activation was modulated via cytokines independently of MR1. MAIT cell-deficient MR1-/- mice showed enhanced weight loss and mortality to severe (H1N1) influenza. This was ameliorated by prior adoptive transfer of pulmonary MAIT cells in both immunocompetent and immunodeficient RAG2-/-gC-/- mice. Thus, MAIT cells contribute to protection during respiratory viral infections, and constitute a potential target for therapeutic manipulation. Key words: Mucosal associated invariant T cell, T cell, infection, influenza virus.
Authors and Affiliations
Rupal Sengar
Keywords
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- EP ID EP484980
- DOI 10.32553/ijmbs.v2i6.63
- Views 59
- Downloads 0
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