The Role of Olive Leaves and Pomegranate Peel Extracts on Diabetes Mellitus Induced in Male Rats
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 71, Issue 5
Abstract
<span>Background: </span><span>Metabolic diseases such as diabetes mellitus (DM) were progressively widespread all over the world and the alteration of oxidative stress and antioxidants associated with DM was established.<br /> </span><span>Aim of the work: </span><span>The natural products were used in many ancient cultures to overcome the DM, so pomegranate peel and olive leaves will be investigated in this work.<br /> </span><span>Materials and Methods: </span><span>Adult male albino rats (</span><span>Sprague Dawley</span><span>), weighing 220-250 g, were used in this study. Animals were classified into five groups, five rats in each group. Control group: rats were served as normal healthy control and were received no treatment but only normal chow diet and water </span><span>ad libitum </span><span>for 4 weeks. Diabetic group: rats were intraperitoneal injected with STZ at dose of 40 mg / kg b. wt. for a single dose. Diabetic and olive leaves extract group: diabetic rats were orally administered with watery extract of olive leaves at dose of 250 mg / kg b. wt. for 4 weeks. Diabetic and pomegranate peel extract group: diabetic rats were orally administered with pomegranate peel at 250 mg / kg b. wt. for 4 weeks. Diabetic and mix of olive leaves & pomegranate peel group: diabetic rats were orally administered with pomegranate peel and olive leaves at 250 mg / kg b. wt. for 4 weeks.<br /> </span><span>Results: </span><span>The oxidative stress markers such as lipid peroxidation and hydrogen peroxide were increased but there was a decrease in the antioxidants makers such as glutathione peroxidase, superoxide dismutase, glucose- 6-phosphate dehydrogenase, reduced glutathione and total antioxidants capacity in the liver of diabetic rats. The expression of insulin receptor and glucose transporter 2 genes was inhibited in liver of diabetic rats. Watery extracts of olive leaves and pomegranate improved the biochemical and molecular changes associated with DM. </span><span>Conclusion: </span><span>The results showed a hypoglycaemic, hypocholesterolemic and hypolipidemic action of olive leaves and pomegranate peel.<br /> </span>
Authors and Affiliations
Eman Helal
Keywords
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