The role of oxytocin, cortizol, homocysteine and cytokines in diabetes mellitus and their association with psychological factors
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2014, Vol 31, Issue 1
Abstract
The mutual interaction of diabetes mellitus (DM) and neuropsychological parameters has been supported, among others, by studies that focus on the neuropsychiatric treatment and care of patients with DM. Neuroendocrine and psychoimmunological parameters have been shown to be associated with both the psychological-psychopathological manifestations and the various aspects of DM. Oxytocin, for example, in addition to its involvement in the contraction of the myometrium during labor and the let-down of milk during lactation has recently been associated with critical aspects of emotion and behavior (e.g. self care, care for others, handling of aggression, etc.). In patients with Prader-Willi syndrome and hypogonadism, the reduced production of oxytocin is associated with the development of DM, and in studies on the administration of injectable oxytocin it was found that it raised the level of plasma insulin. Homocysteine, which has recently been the focus of both clinical practice and research, has been correlated with the development of coronary artery disease in patients with type 2 DM. Other studies have identified a causal relationship of homocysteine in depression and aggression. There is experimental and clinical documentation of a bilateral communication between the central nervous system (CNS) and various immune factors, including the cytokines, interleukin-6 (IL-6), IL-12 and tumor necrosis factor (TNF), but also indications of their involvement in the onset and persistence of both neuropsychological disorders (depression, anxiety disorders) and DM. In addition, correlation has been demonstrated of lipid parameters both with DM and with neuropsychological disorders such as depressive syndrome and anxiety disorders.
Authors and Affiliations
K. KONTOANGELOS, C. PAPAGEORGIOU, A. RAPTIS, P. TSIOTRA, E. BOUTATI, G. PAPADIMITRIOU, S. RAPTIS
Keywords
Related Articles
- EP ID EP115639
- DOI -
- Views 67
- Downloads 0
Hepatosplenomegaly in a patient with rheumatoid arthritis treated with methotrexate
The case is reported of a 79 year-old female with rheumatoid arthritis, receiving treatment with methotrexate, who presented with hepatomegaly, splenomegaly, leukopenia and hypergammaglobulinemia. The diagnosis of viscer...
Stress, burnout, mental health and coping strategies among the staff of Greek correctional institutions
OBJECTIVE The aim of this study was the documentation of the mental health status, the degree of stress and professional burnout, and the coping strategies of employees in Greek correctional institutions. METHOD Of 86...
Pulmonary sequestration on the left lower lobe
No abstract available
Σωματική δραστηριότητα 28.030 ανδρών και γυναικών στην ελληνική έρευνα του ΕΠΙΚ
ΣΚΟΠΟΣ Η εκτίμηση του επιπέδου σωματικής δραστηριότητας στον ελληνικό πληθυσμό. ΥΛΙΚΟ-ΜΕΘΟΔΟΣ Η εκτίμηση της σωματικής δραστηριότητας των Ελλήνων συμμετεχόντων στο Ευρωπαϊκό Πρόγραμμα Συνεργασίας Ιατρικής και Κοινωνί...
Accessory navicular ossicle (or os naviculare or os tibiale externum)
No abstract available