The role of pepsin in the laryngopharyngeal reflux
Journal Title: Otolaryngologia Polska - Year 2017, Vol 71, Issue 6
Abstract
Laryngopharyngeal reflux (LPR) is a common defect among laryngological and phoniatric patients. Although LPR is categorized as a superficial gastroesophageal reflux disease (GERD), differential diagnosis should treat these two diseases separately. LPR symptoms can be assessed in the interview using as a tool the reflux symptom index (RSI). In addition, changes in the larynx that occur during LPR might be seen during laryngoscopy and classified according to the reflux finding score (RFS). One of the main mucosal irritants in LPR is pepsin which digests proteins and impairs the functions of the upper respiratory tract cells by affecting carbonate anhydrase (CAIII) and the Sep 70 protein. Pepsin initiates inflammatory changes within the larynx, nasopharynx and nasal cavity. The use of pepsin detection in upper and lower throat secretions is a new direction in LPR diagnostics.<br/><br/>
Authors and Affiliations
Katarzyna Kowalik, Antoni Krzeski
Keywords
Related Articles
- EP ID EP245583
- DOI 10.5604/01.3001.0010.7194
- Views 76
- Downloads 0
Diagnostic imaging in chronic otitis media: does CT and MRI fusion aid therapeutic decision making? – a pilot study
Introduction: Despite the recent advances in otosurgery diagnosis of cholesteatoma and qualification for surgery remains an issue in contemporary laryngology. In cases of cholesteatoma recidivism, it is of utmost importa...
Doświadczenia w operacjach raka krtani z ostatnich 35 lat na Oddziale Laryngologii Szpitala Wojewódzkiego w Zielonej Górze
Introduction. For many years, we are operating tumor conditions of the larynx, and periodically we evaluate our work. It is important as it allows us to compare the operational materials and the results of treatments. Ma...
Szkliwiak zatoki szczękowej – opis przypadku
Ameloblastoma (adamantinoma) is a benign neoplasm deriving from the enamel organ. Its etiology has not been ultimately determined. It constitutes about 1% of all head and neck tumours, and about 11% of teeth-originating...
Optymalizacja leczenia chorych z perlakiem ucha środkowego
SUMMARY Background: The chronic otitis media is a frequent condition in ENT practice. The presence of cholesteatoma can lead to the destruction of bony structures in the middle ear spaces to a different extent. Aim: We d...
Przypadek czerniaka złośliwego trąbki słuchowej
Melanomas of the mucous membranes of airway tract constitute around 1% of the total melanomas of head and neck. The most common site of the tumor are the nasal and paranasal sinuses but melanomas of the oral cavity are d...