The role of PLUNC proteins in the etiopathogeny of chronic rhinosinusitis
Journal Title: Romanian Journal of Rhinology - Year 2015, Vol 5, Issue 19
Abstract
BACKGROUND. Innate immunity represents the first way of protection against different pathogenic agents. Recently, it has been a permanent interest regarding an innate immune molecule, that is known as palate, lung, nasal epithelial clone (PLUNC). PLUNC is a specific result found in the airways, of approximately 25 kDa, whose encoding is realized by adjacent genes located within a region of 300 kb in chromosome 20; these proteins must be detected predominantly in the superior respiratory tract. MATERIAL AND METHODS. We performed a prospective clinical study on 34 patients with chronic rhinosinusitis and 10 controls, in order to investigate the expression of this protein in nasal tissue of patients affected by chronic rhinosinusitis. We tested the correlation between the existence of this disease and PLUNC proteins positivity. RESULTS. 100% of controls have a+++ rated PLUNC proteins positivity, while cases have a lower percentage of positivity. There were no differences statistically significant between patients with CRSwNP and those with CRSsNP. CONCLUSION. As a response to different irritating agents (bacteria, viruses, chemical factors), nasal mucosa will react by producing PLUNC proteins. PLUNC proteins have a defensive role in the upper airways mucosa
Authors and Affiliations
Claudiu Manea, Codrut Sarafoleanu, Cristina Iosif, Elena Patrascu
Keywords
Related Articles
- EP ID EP535956
- DOI 10.1515/rjr-2015-0018
- Views 82
- Downloads 0
Squamous cell carcinoma of the pterygopalatine fossa - A case report
The pterygopalatine fossa is an inverted pyramid-shaped space of the viscerocranium, protected by bony structures. Surgical access to this anatomical space is difficult, especially for tumor resection. There are numerous...
Noninvasive fungal rhinosinusitis
Fungus ball (FB) of the paranasal sinuses has a distinctive clinicopathological presentation. The disease occurs more frequently in elderly patients and has a female preponderance. Classically, it involves only one paran...
A paradigm shift: “Defect of the fontanel” instead of “Accessory ostium” and classified nasal septal deformities instead of “septal deviation”
OBJECTIVES. The purpose of this article is to highlight some terms which have been ingrained in the rhinosinusology literature. MATERIAL AND METHODS. It regards the term “accessory ostium” and the term “septal deviation”...
The role of CT scan in predicting complications in small ethmoidal osteomas
Osteomas are slow-growing tumors of the paranasal sinuses, usually found in the frontal and ethmoidal sinus. In many cases, these tumors are discovered by chance or after an imagistic exam for a non-responsive to medical...
Crista galli sinusitis – a radiological impression or a real clinical entity
BACKGROUND. Crista galli is an anatomical structure localized in the midline, that derives from the ethmoid bone, with a compact bone structure, sometimes pneumatized. The connection between the pneumatized crista galli...