The Role of Prophylactic Lymph Node Dissection in Patients with Intrahepatic Cholangiocarcinoma
Journal Title: Journal of Surgery - Year 2016, Vol 4, Issue 2
Abstract
Purpose: We investigated the role of prophylactic lymph node dissection (LND) in patients with intrahepatic cholangiocarcinoma (ICC). Methods: A retrospective analysis was performed evaluating the impact on survival of prophylactic LND and preoperative risk factors for histological lymph node metastasis (LNM) in a cohort of 49 patients with ICC of the mass-forming type, who underwent curative resection between 1995 and 2013. Results: There were no differences in both disease-free survival (DFS) and overall survival (OS) between the patients without LND and the patients with LND who did not have LNM. Multivariate analysis revealed that serum CA19-9 level > 150 U/mL and LN size > 5 mm on preoperative computed tomography (CT) were the significant preoperative risk factors for LNM. None of the patients with LN size < 5 mm on preoperative CT and serum CA19-9 level ≤ 150 U/mL had LNM. Conclusions: Prophylactic LND did not significantly improve DFS orOS in the present study. Regional LND could be omitted for patients with LN size < 5 mm in preoperative CT and serum CA19-9 level ≤ 150 U/mL who are unlikely to have LNM.
Authors and Affiliations
Daisuke Satoh
Keywords
Related Articles
- EP ID EP203828
- DOI 10.13188/2332-4139.1000031
- Views 155
- Downloads 0
Atypical Necrobiotic Xanthogranuloma Associated with Epidermodysplasia Verruciformis
Necrobiotic xanthogranuloma is a rare, idiopathic, and chronic systemic granulomatous disorder that is usually associated with paraproteinemia of the immunoglobulin (Ig)G kappa (κ) type. It is clinically characterized by...
Comparative Study between Alvarado Score& Ripasa Score in Diagnosis of Acute Appendicitis
Background: Acute appendicitis is one of commonest surgical emergencies, and it is more prevalent in the second and third decades and decreasing with age. Up-till now there are no laboratory parameters that could indicat...
Phytotherapy for Benign Prostatic Hyperplasia: The Clinical Efficay and Safety of Use of Prostacare in Patients with Mild to Moderate Lower Urinary Tract Symptoms
Background: Benign prostatic Hyperplasia (BPH) is the commonest benign tumour affecting men worldwide often causing structural or functional obstruction of the bladder neck with manifestation of lower urinary tract sympt...
The Donor Risk Score: A Simpler Method to Grade Liver Allografts
Context: Growing need for liver transplantation has led to increased efforts to utilize allografts for transplantation from an expanding donor pool (“marginal” donor livers). Objective: To devise a simplified practical...
Therapeutic Ultrasound: Osteoarthritis Symptom-Modification and Potential for Disease Modification
Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. While joint replacement surgery is a common treatment option for end-stage disease, non-surgical management is critical for pre...