The role of prophylactic radiotherapy in prevention of brain metastasis
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 73, Issue 2
Abstract
Despite of these side effects, many studies concluded that the benefits of prophylactic brain radiation in prevention and delaying the spread of cancer overcome its harmful effects. This review aimed to evaluate the literature assessing the role of prophylactic radiotherapy in prevention of metastasis to the brain tissues, measure its incidence and the overall survival rates in patient with lung cancer to provide evidence-based data <strong>Methods</strong>: Electronic search was performed in Medline using Pubmed resulted in 107 eligible studies. The titles and abstracts of all these articles, was screened and based on this reading studies excluded due to irrelevancy or duplication. <strong>Results</strong>: Search of the literature identified total of 107 studies, after exclusion of irrelevant, duplicated and review studies, five studies were included in the review as they met the inclusion criteria. The included studies pointed to assess the effect of prophylactic radiotherapy in avoidance of brain metastasis. All included studies were randomized controlled trials. Total numbers of 1399 patients were recruited in the included studies. Age of patients range from 39 up to 84 years old or more. Small-cell lung cancer was the primary cancer in three of the included studies. One of the included studies assessed patients with non-small cell lung cancer and one study included patients with small cell anaplastic bronchogenic carcinoma. <strong>Conclusions:</strong> The use of prophylactic radiotherapy is effective in reduction of incidence of brain metastasis, but it had no role in rising of the overall survival.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584429
- DOI 10.12816/ejhm.2018.12364
- Views 115
- Downloads 0
Driving Eligibility among Epilepsy Patients in Saudi Arabia Ali Jaffr Al Taho
Background: epilepsy is prevalent neurological disorder in Saudi Arabia and listed as temporary or permanent driving interdiction. In line with other countries rules and requirements, would be safer, for the patient and...
Assessment of Early Left Ventricular Diastolic Dysfunction in Patients with Metabolic Syndrome by 2D Speckle Tracking Echocardiography
<span>Background: </span><span>Metabolic syndrome predisposes to left ventricular dysfunction and heart failure, early </span> <span>detection of associated subclinical cardiac changes has important diagnostic and progno...
Role of Recent Imaging Modalities in Diagnosis of Diabetic Foot
Background: osteomyelitis and septic arthritis complicate up to one third of diabetic foot infections that require hospitalization and often result from contaminated soft tissues. Early diagnosis is difficult to achieve...
Perceptions about Sickle Cell Disease among Adults in Albaha Region: A Cross-sectional Study
Background: Sickle-cell disease (SCD) is a group of genetic disorders characterized by abnormally shaped red blood cells (RBCs), which are destroyed at increased rates, leading to anemia. Recently, Saudi Arabia has been...
Confidence, Perception, and Attitude towards Prescribing Antibiotics among Medical Students and Interns in Jeddah, Saudi Arabia
<span>Background: </span><span>According to the World Health Organization, antibiotics are the most frequently prescribed drugs worldwide. The development of antibiotics has successfully overcome the threat of infectious...