The Role of Protein Kinase mTOR in Th2 Polarization of the Immune Response in Bronchial Asthma in Сhildren
Journal Title: Здоров`я дитини - Year 2015, Vol 7, Issue 67
Abstract
Objective of this study was to determine whether single-nucleotide polymorphism (SNP) in mTOR gene is associated with development of allergic phenotype in children. Methods. Genotyping for mTOR (rs11121704) was performed in the following populations: patients with asthma (n = 91; ages 5–18 years), and control group (n = 87; ages 5–18 years) using real-time polymerase chain reaction. Results. We have found that 50 (54.9 %) of patients from the study group and 43 (49.4 %) subjects from the control group had major allele of rs11121704 in mTOR, 36 (39.6 %) and 32 (36.8 %), respectively, — heterozygous allele, and 5 (5.5 %) and 12 (13.8 %) — minor allele. Variants of rs11121704 minor genotype in the gene mTOR were 2.5 times more likely in the control group than among patients of the study group. Conclusions. We supposed that SNP in mTOR may independently serve as perspective marker to predict the development of asthma and other allergic diseases among children.
Authors and Affiliations
O. P. Volosovets, S. P. Kryvopustov, O. V. Pavlyk
Keywords
Related Articles
- EP ID EP217424
- DOI -
- Views 98
- Downloads 0
The role of microRNA in diseases of the biliary system
This literature review provides current information about role of microRNA in diseases of the biliary system. For writing the article, we used such databases, as Scopus, Web of Science, MedLine, PubMed, Google Scholar, C...
Clinical case of retrobulbar abscess in a newborn child
Some rare cases from medical practice are interesting for their uniqueness, especially if they have severe complications or atypical clinical course. The retrobulbar abscess is a serious condition threatening child’s li...
Ultrasound and Biochemical Indices of Endothelial Dysfunction at Hemorrhagic Vasculitis in Children
60 children with hemorrhagic vasculitis were examined in order to detect ultrasound and biochemical markers of endothelial dysfunction, depending on the degree of activity and the form. Serum monocyte chemoattractant pr...
Step-Down Antibiotic Therapy of Community-Acquired Pneumonia in Children with Burdened Allergologic History and Concomitant Allergic Pathology: Focus on Cefpodoxime Proxetil
The use of cefpodoxime proxetil in children with community-acquired pneumonia is effective. In patients with burdened history of allergic events and concomitant allergic pathology, use of cefpodoxime proxetil does not ca...
Role of the Gut Microbiota in the Development of Lipid and Carbohydrate Metabolism in the Liver Steatosis in Children
Background. Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance, dyslipidemia and obesity. Recent evidence supports a role of the gut microbiota in the pathogenesis of NAFLD. Changes in the mi...