The role of regulatory T cells in immune dysfunction during sepsis
Journal Title: World Journal of Emergency Medicine - Year 2015, Vol 6, Issue 1
Abstract
BACKGROUND: Although regulatory T cells (Tregs) are key to the maintenance of immunologic homeostasis and tolerance, little is known about Treg-mediated immunosuppression in the stage of sepsis. This article aimed to review the current literature on the role of Tregs in the pathophysiology of septic response, attempting to investigate the role of Tregs in immune dysfunction during sepsis. DATA SOURCES: A literature search was conducted in January 2014 using the China National Knowledge Infrastructure and PubMed. Articles on the role of Tregs in immune dysfunction during sepsis were identified. RESULTS: The identified articles indicated that Treg levels can be used for the assessment of the course of sepsis. The inhibition of Treg activity can promote the recovery of immune function. CONCLUSION: Since the mechanism of Tregs is complex during the sepsis, more studies are needed.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP470251
- DOI -
- Views 56
- Downloads 0
Stroke due to Bonzai use: two patients
Synthetic cannabinoids are increasingly used all over the world as marijuana substitutes. They have various names such as spice and bonzai in different countries. Cardiovascular or cerebrovascular events associated with...
S100B protein in serum is elevated after global cerebral ischemic injury
BACKGROUND: S100B protein in patients with cardiac arrest, hemorrhagic shock and other causes of global cerebral ischemic injury will be dramatically increased. Ischemic brain injury may elevate the level of serum S100B...
Trends in mortality of emergency departments patients in China
BACKGROUND: Emergency medical service system (EMSS) in China is becoming more important. However, studies on mortality of emergency departments (EDs) patients in tertiary hospitals and on the trends in mortality of ED pa...
Emergency physician's perception of cultural and linguistic barriers in immigrant care: results of a multiple-choice questionnaire in a large Italian urban emergency department
BACKGROUND: A poor communication with immigrants can lead to inappropriate use of healthcare services, greater risk of misdiagnosis, and lower compliance with treatment. As precise information about communication between...
Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times
BACKGROUND: The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) on the onset of acute cerebral infarction (ACI) at different time points of the first 6 hours. METHODS: A...