The role of stem cells in limb regeneration
Journal Title: Organogenesis - Year 2016, Vol 12, Issue 1
Abstract
Limb regeneration is a complex yet fascinating process observed to some extent in many animal species, though seen in its entirety in urodele amphibians. Accomplished by formation of a morphologically uniform intermediate, the blastema, scientists have long attempted to define the cellular constituents that enable regrowth of a functional appendage. Today, we know that the blastema consists of a variety of multipotent progenitor cells originating from a variety of tissues, and which contribute to limb tissue regeneration in a lineage-restricted manner. By continuing to dissect the role of stem cells in limb regeneration, we can hope to one day modulate the human response to limb amputation and facilitate regrowth of a working replacement.
Authors and Affiliations
Elizabeth R. Zielins, Ryan C. Ransom, Tripp E. Leavitt, Michael T. Longaker, Derrick C. Wan
Keywords
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- EP ID EP679823
- DOI 10.1080/15476278.2016.1163463
- Views 26
- Downloads 0
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The role of stem cells in limb regeneration
Limb regeneration is a complex yet fascinating process observed to some extent in many animal species, though seen in its entirety in urodele amphibians. Accomplished by formation of a morphologically uniform intermediat...