The Role Of T Helper Cytokines In Indeterminate Colitis
Journal Title: National Journal of Integrated Research in Medicine - Year 2011, Vol 2, Issue 1
Abstract
Background: Indeterminate colitis is one of the inflammatory bowel diseases that cannot be classified over time as having ulcerative colitis or Crohn’s disease. Dysregulated immunity has been implicated in indeterminate colitis.Aim: to measure serum levels of pro-inflammatory cytokines (tumor necrosis factor (TNF- α), interferon-gamma (IFN-γ) and IL-6 and anti-inflammatory cytokines IL-10 in indeterminate colitis patients. Methods: A cross- sectional study carried out in Al-Kindi Teaching Hospital, Baghdad city from 2007 - 2010. Sixty patients with indeterminate colitis participated in the study. Serum levels of cytokines (IL-6, IL-10, TNF-alpha and IFN-gamma were done by Enzyme Linked Immuno Sorbent Assay (ELISA) and compared with age and sex matched thirty healthy controls. Results: There is a significant increased in IL-10 (p=0.003) and IFN-gamma (p=0.0001) in indeterminate colitis patients. TNF-alpha was significantly decreased (p=0.0001) while IL-6 showed no significance different with control group(p=0.735).Conclusions: There is increase in IL-10 and INFgamma levels and decrease in TNF-alfa levels in patients with IC.
Authors and Affiliations
Batool Mutar Mahdi
Keywords
Related Articles
- EP ID EP102744
- DOI -
- Views 144
- Downloads 0
Menstrual Pattern of Adolescent School Girls of Bhavnagar (Gujarat)
Background: Menstruation is a normal physiological phenomenon for females indicating her capability for procreation. However this normal often associated with some degree of sufferings and embarrassment. The prevalence...
Involvement of Autonomic Nervous System in Isometric Handgrip in Healthy Young Subject
Background: HRV can be considered a relatively simple, noninvasive and sensitive method for studying autonomic modulation, purpose of the present study was to determine whether readily measured blood pressure (BP) ind...
Sexual Dimorphism of Bicondylar width of Femora
Background: Sexual identification from the skeletal parts is very important medicllegaly as well as anthropologicaly. Present study aims to ascertain values of femoral bicondylar width and to evaluate its possible e...
A Study of the Effect of Cigarette Smoking On Cognitive Parameters In Human Volunteers
Introduction: Nicotine, one of the major alkaloids of cigarette smoke, is known to stimulate the CNS. It was thought worthwhile to study effect after single cigarette smoking on some cognitive functions. These effects ma...
The Effect of Marble Dust on Different Pulmonary Parameters in Marble Factory Workers
There are numbers of marble factories are found in Agra, UP, India and the numbers of workers perform their duties to those factories to maintain their family wages. Majority of the workers are habituated to smoke duri...