The Role Of T Helper Cytokines In Indeterminate Colitis
Journal Title: National Journal of Integrated Research in Medicine - Year 2010, Vol 1, Issue 5
Abstract
Background: Indeterminate colitis is one of the inflammatory bowel diseases that cannot be classified over time as having ulcerative colitis or Crohn’s disease. Dysregulated immunity has been implicated in indeterminate colitis.Aim: to measure serum levels of pro-inflammatory cytokines (tumor necrosis factor (TNF- α), interferon-gamma (IFN-γ) and IL-6 and anti-inflammatory cytokines IL-10 in indeterminate colitis patients. Methods: A cross- sectional study carried out in Al-Kindi Teaching Hospital, Baghdad city from 2007 - 2010. Sixty patients with indeterminate colitis participated in the study. Serum levels of cytokines (IL-6, IL-10, TNF-alpha and IFN-gamma were done by Enzyme Linked Immuno Sorbent Assay (ELISA) and compared with age and sex matched thirty healthy controls. Results: There is a significant increased in IL-10 (p=0.003) and IFN-gamma (p=0.0001) in indeterminate colitis patients. TNF-alpha was significantly decreased (p=0.0001) while IL-6 showed no significance different with control group(p=0.735).Conclusions: There is increase in IL-10 and INFgamma levels and decrease in TNF-alfa levels in patients with IC.
Authors and Affiliations
Batool Mutar Mahdi
Keywords
Related Articles
- EP ID EP40114
- DOI -
- Views 320
- Downloads 0
Transplacental Transport of Fluoride, Calcium and Magnesium
Background: In fluorosis endemic area, the amount of fluoride transferred to the fetus is significant in determining the early onset of fluorosis. The role played by placenta in transporting fluoride and other ions whi...
Pancreaticoduodenectomy With Left Lateral Hepatic Segmentectomy : A Rare Procedure For The Management Of Complex Pancreaticoduodenal And Liver Injuries In Blunt Abdominal Trauma
Context : Pancreaticoduodenal complex injuries are uncommon after blunt abdominal trauma and are difficult to diagnose. Case Report : We report a case of 25 years old male who suffered massive Pancreaticoduodenal compl...
A large incidental adrenal mass in a patient with sudden onset multiple organ failure
A 55-year-old female was brought to the emergency room for sudden-onset chest pain and shortness of breath. Her only past medical history was mild hypertension not requiring medications. She had no family history of cor...
TWO CASES OF SCHIZOPHRENIA; THE RELATIONSHIP BETWEEN CAVUM SEPTUM PELLUCIDUM AND CLINICAL COURSE
Septum pellucidum, which forms the medial wall of the lateral ventricles, consists of two laminates. Cavum septum pellucidum (CSP) is defned when there is a space between these laminae. In some MRI studies have shown a...
Application Based Learning Through Hospital Projects For Teaching Microbiology To Medical Students
Microbiology in-spite of being a crucial subject for understanding the basic principles with their application in infectious disease fails to impress the undergraduate medical students probably because they are taught...