The Role Of T Helper Cytokines In Indeterminate Colitis
Journal Title: National Journal of Integrated Research in Medicine - Year 2010, Vol 1, Issue 5
Abstract
Background: Indeterminate colitis is one of the inflammatory bowel diseases that cannot be classified over time as having ulcerative colitis or Crohn’s disease. Dysregulated immunity has been implicated in indeterminate colitis.Aim: to measure serum levels of pro-inflammatory cytokines (tumor necrosis factor (TNF- α), interferon-gamma (IFN-γ) and IL-6 and anti-inflammatory cytokines IL-10 in indeterminate colitis patients. Methods: A cross- sectional study carried out in Al-Kindi Teaching Hospital, Baghdad city from 2007 - 2010. Sixty patients with indeterminate colitis participated in the study. Serum levels of cytokines (IL-6, IL-10, TNF-alpha and IFN-gamma were done by Enzyme Linked Immuno Sorbent Assay (ELISA) and compared with age and sex matched thirty healthy controls. Results: There is a significant increased in IL-10 (p=0.003) and IFN-gamma (p=0.0001) in indeterminate colitis patients. TNF-alpha was significantly decreased (p=0.0001) while IL-6 showed no significance different with control group(p=0.735).Conclusions: There is increase in IL-10 and INFgamma levels and decrease in TNF-alfa levels in patients with IC.
Authors and Affiliations
Batool Mutar Mahdi
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