THE ROLE OF THE CLINICAL AND MOLECULAR ASSAYS IN PROSTATE CANCER DETECTION
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2017, Vol 10, Issue 6
Abstract
To assess the correlation between the clinical and molecular assays in identify early and robust prostate cancer detection. Early detection, management of cancer and decision about the disease are important for beneficial treatment of prostate cancer. We used a computerized search of the Medline/ PubMed databases with the key words prostate cancer, biomarker, and early detection. Clinical management of cancer is facilitated by a conventional test such as prostate-specific antigen and digital rectal exam for application in clinical practice. Although these tests have significantly reduced the mortality with prostate cancer, but have some drawbacks and false positive rate. Fortunately, there are strong correlations between the clinical and molecular assays in identifying early and robust cancer detection, because molecular assays are less invasive and reliable. The use of genetic markers has the potential to providing useful prognostic or predictive information into clinically useful diagnostic tests to improve clinical decision-making and enhance therapeutic success. Different clinical and molecular assays are for detecting prostate cancer and use the biomarkers as potential tumor markers could be a useful predictor in the screening and monitoring to avoid over treatment prostate cancer.
Authors and Affiliations
Fatemeh Mansouri
Keywords
Related Articles
- EP ID EP605288
- DOI 10.22159/ajpcr.2017.v10i6.17490
- Views 134
- Downloads 0
SYNTHESIS AND OPTIMIZATION OF GEMCITABINE-LOADED MIL-101NH2 (Fe) NANOCARRIERS: RESPONSE SURFACE METHODOLOGY APPROACH
Objective: The objective of the present study is to synthesize and optimize gemcitabine (GEM)-loaded MIL-101NH2 (Fe) nanocarriers. The design of experiments is used to optimize the formulation for higher encapsulation ef...
ASSESSMENT OF PROFESSIONAL’S ADHERENCE TO JOINT NATIONAL COMMITTEE 8 GUIDELINES IN THE MANAGEMENT OF HYPERTENSION
Objectives: Hypertension is the most insidious ailment in primary care with its management being a daily affair. The avail of antihypertensive medications has affirmed their efficacy in blood pressure alleviation. Yet, t...
ANALYSIS OF PHYTO-CONSTITUENTS, ANTIOXIDANT, AND ALPHA AMYLASE INHIBITORY ACTIVITIES OF PERSEA AMERICANA MILL., RHODODENDRON ARBORETUM SM. RUBUS ELLIPTICUS SM. FROM ARGHAKHANCHI DISTRICT NEPAL
Objective: To evaluate the phytochemical, antioxidant activities, and α-amylase inhibition assay for methanolic extract of three ethnomedicinal plants, namely Persea americana Mill., Rubus ellipticus Sm., and Rhododendr...
COLON SPECIFIC DELIVERY OF COMBINATION OF 5-FLUOROURACIL AND CELECOXIB: PREPARATION, CHARACTERIZATION, AND IN VITRO CYTOTOXICITY ASSAY
Objective: 5-Fluorouracil (5-FU) and celecoxib (Cel) combination offered additive effect in the treatment of colon cancer. However, physicochemical and biopharmaceutical attributes of both drugs deliver suboptimal concen...
PROBIOTICS: THE UNDERVALUED CONQUERORS
ABSTRACTProbiotics or “beneficial microorganisms†have recently acquired the status of blockbusters in the pharmaceutical industry. Despite being commerciallyavailable, little is known about the magnitude to which th...