The role of the clinical pharmacologist in animal health
Journal Title: The AAPS Journal - Year 2002, Vol 4, Issue 4
Abstract
Like most scientific disciplines, pharmacology is replete with subspecialties. Certainly most scientists recognize the value of animal studies in drug development for human pharmaceuticals. However, animals as the target species also represent a major focus of investigation. According to recent estimates, in the United States for the year 2000, 98.1 million cattle, 59.8 million pigs, and 1.5 billion chickens existed. Added to that estimate were companion animals, including 4 million horses, 59 million cats, and 52.9 million dogs1,2. The estimate does not include the so?called “minor” species, such as 7 million sheep and 320 000 acres of freshwater fish production1,3. In most respects, the medical needs of these animals are addressed in a manner parallel to that of human medicine. One such parallel, with certain distinct differences from its human counterpart, is veterinary clinical pharmacology.
Authors and Affiliations
Cory Langston, Cyril R. Clarke
Keywords
Related Articles
- EP ID EP682039
- DOI 10.1208/ps040436
- Views 96
- Downloads 0
Effect of Device Design on the In Vitro Performance and Comparability for Capsule-Based Dry Powder Inhalers
The online version of this article (doi:10.1208/s12248-012-9379-9) contains supplementary material, which is available to authorized users.
Estimation of capping incidence by indentation fracture tests
The purpose of this study was to predict the capping tendencies of pharmaceutical powders by creating indentation fracture on compacts. Three sets of binary mixtures containing different concentrations of each ingredient...
An interactive algorithm for the assessment of cumulative cortisol suppression during inhaled corticosteroid therapy
The objective of the study was to develop an algorithm based on a pharmacokinetic-pharmacodynamic (PK/PD) modeling approach to quantify and predict cumulative cortisol suppression (CCS) as a surrogate marker for the syst...
Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update
The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-binding cassette (ABC) efflux transporter. It was so named because it was initially cloned from a multidrug-resistant breast cancer cell line...
Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans
To investigate the potential added value of intranasal drug administration, preclinical studies to date have typically used the area under the curve (AUC) in brain tissue or cerebrospinal fluid (CSF) compared to plasma f...