The Role of Visceral Adipose Tissue in the Development of Hormonal and Metabolic Disorders in Patients with Diabetes Mellitus Type 2, Obesity and Arterial Hypertension
Journal Title: Міжнародний ендокринологічний журнал - Year 2014, Vol 4, Issue 60
Abstract
The article presents the results of adipokines (leptin and adiponectin) level study, as well as insulin resistance and secretory activity of the β-cells of the pancreas, depending on the amount of adipose tissue and its distribution type, studied using dual-energy X-ray absorptiometry, in 106 patients (50 men and 56 women aged 55.90 ± 2.15 years) with diabetes mellitus (DM, type 2, obesity and arterial hypertension, as compared with the control group (without DM, obesity, and hypertension). It has been shown that an excess amount of adipose tissue in patients with DM type 2 affects the development of hormone-metabolic disorders related to the features of adipokines production. It was found that overproduction of leptin by adipose tissue and decreased basal level of adiponectin in obesity create conditions to decrease the sensitivity of target cells to insulin-mediated glucose uptake, defatigation and subsequent depletion of the secretory function of β-cells of the pancreas, as well as to the maintenance of steady state of resistance to insulin and glucose homeostasis deviation towards hyperglycemic conditions prevail. Also there been shown physiologically determined sexual dimorphism of adipokines level conditioning higher tolerance of the female body to excess of adipose tissue mass. It was confirmed that the state of hyperleptinemia and hypoadiponectinemia underlie disorders of carbohydrate metabolism in patients with DM 2 with obesity and hypertension.
Authors and Affiliations
K. O. Zuyev
Keywords
Related Articles
- EP ID EP226934
- DOI -
- Views 57
- Downloads 0
Clinical and pathogenetic importance of hormonal natriuretic peptides in gout
Background. In addition to purine metabolism disorders, systems of pro-inflammatory cytokines, matrix metalloproteinases and eicosanoids, various medium molecular weight compounds can participate in the pathogenesis of g...
Influence of Hyperhomocysteinemia on Development of Non-Alcoholic Fatty Liver Disease in Diabetes Mellitus
In 137 patients with diabetes mellitus, non-alcoholic fatty liver disease and with combination of these diseases there had been studied the pathogenetic mechanisms of hyperhomocysteinemia influence on formation of non-al...
Diabetes Mellitus and Some Microelements
This literature review describes the role of the different trace elements in the development, progression and prevention of diabetes mellitus and its complications. The results of the studies of microelements in blood, u...
Synevo Day 2019: “Laboratory diagnosis — tomorrow that has come” (review of the conference)
.
Role of Obesity in the Progression of Diabetic Nephropathy in Patients with Diabetes Mellitus (Literature Review)
The prevalence of obesity has risen proportionally to epidemic and continues to be a major health problem worldwide. The high prevalence of obesity is closely associated with the increased incidence of chronic diseases,...